A novel efficient one-pot method for the preparation of 2-aminofurans was developed based on multicomponent reaction of 3-hydroxy-4H-pyran-4-ones, α-ketoaldehydes and methylene active nitriles. A distinctive feature of the proposed approach is the formation of 2-aminofurans in contrast to related literature methods leading to 2-aminopyrans. The advantages of this synthesis include high yields, mild reaction conditions, atom economy and easy workup procedure, which can avoid chromatographic purifications. The structure of one of the 2-aminofuran derivatives was determined by X-ray diffraction.

中文翻译：

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通过3-羟基-4 H-吡喃-4-酮，α-酮醛和亚甲基活性腈的多组分反应，新颖的一锅法制备2-氨基呋喃衍生物

基于3-羟基-4 H-吡喃-4-酮，α-酮醛和亚甲基活性腈的多组分反应，开发了一种新型的高效一锅法制备2-氨基呋喃。与导致2-氨基吡喃的相关文献方法相反，所提出的方法的显着特征是2-氨基呋喃的形成。这种合成的优点包括高收率，温和的反应条件，原子经济性和易于后处理的步骤，可以避免色谱纯化。通过X射线衍射确定2-氨基呋喃衍生物之一的结构。