Schizophrenia has prominent functional dysconnectivity, especially in the prefrontal cortex (PFC). However, it is unclear whether in the same group of patients with schizophrenia, PFC functional dysconnectivity appears in an organized manner or is stochastically located in different subregions. By investigating the resting-state functional connectivity (rsFC) of each PFC subregion from the Brainnetome atlas in 40 schizophrenia patients and 40 healthy subjects, we found 24 altered connections in schizophrenia, and the connections were divided into four categories by a clustering analysis: increased connections within the PFC, increased connections between the inferior PFC and the thalamus/striatum, reduced connections between the PFC and the motor control areas, and reduced connections between the orbital PFC and the emotional perception regions. In addition, the four categories of rsFC showed distinct cognitive engagement patterns. Our findings suggest that PFC subregions have specific functional dysconnectivity patterns in schizophrenia and may reflect heterogeneous symptoms and cognitive deficits in schizophrenia.

精神分裂症具有突出的功能障碍，特别是在额叶前皮质（PFC）中。但是，尚不清楚在同一组精神分裂症患者中，PFC功能性连接障碍是有组织地出现还是随机地位于不同的子区域。通过调查40名精神分裂症患者和40名健康受试者的脑图谱图谱中每个PFC子区域的静止状态功能连通性（rsFC），我们发现精神分裂症中有24种改变的连接，并且通过聚类分析将连接分为四类：增加PFC内的连接，下PFC与丘脑/纹状体之间的连接增加，PFC与运动控制区域之间的连接减少以及眼眶PFC与情绪感知区域之间的连接减少。此外，rsFC的四个类别显示出不同的认知参与模式。我们的发现表明，PFC子区域在精神分裂症中具有特定的功能不连通性模式，并且可能反映了精神分裂症的异质症状和认知缺陷。