Synergistic combined treatments are currently practiced in clinics for the management of several neoplasms. While surgery, radiotherapy, and chemotherapy remain as the standards of care for monomodal and co-treatments, emerging modalities like hyperthermia (HT) demonstrate promising features as (neo)adjuvant, particularly for recurrent cancers. However, the clinical relevance of HT is still debated due to a number of challenges, such as tumor specific temperature increase, uneven heating of the target, and the lack of agents that concurrently execute HT in combination with radio- and/or chemotherapy.

Here, the application of non-persistent ultrasmall-in-nano gold architectures for synergistic chemo-photothermal treatment of head and neck squamous cell carcinomas (HNSCCs) is presented. The nano-architectures are composed of excretable narrow near-infrared (NIR)-absorbing gold ultrasmall nanoparticles and an endogenously double controlled cisplatin prodrug. The efficiency of the nano-architectures is evaluated on three-dimensional (3D) models of HNSCCs with positive or negative human papillomavirus (HPV) status. The combined treatment causes a more pronounced antitumor action on HPV-positive HNSCCs. Overall, the findings demonstrate the potential clinical relevance of translatable noble metal-based synergistic treatments in tumors management.

目前在临床实践中采用协同联合治疗来治疗几种肿瘤。尽管手术，放疗和化学疗法仍然是单峰和联合治疗的治疗标准，但新兴疗法如高温（HT）表现出作为（新）佐剂的有希望的特征，特别是对于复发性癌症。但是，由于许多挑战，例如肿瘤特异性温度升高，靶标加热不均匀以及缺乏与放疗和/或化疗同时执行HT的药物，因此HT的临床相关性仍在争论中。

在这里，提出了非持久性纳米纳米超小金结构在头颈部鳞状细胞癌（HNSCC）的协同化学光热治疗中的应用。纳米结构由可吸收的吸收近红外（NIR）的金超小纳米颗粒和内源性双控顺铂前药组成。在具有阳性或阴性人类乳头瘤病毒（HPV）状态的HNSCC的三维（3D）模型中评估了纳米架构的效率。联合治疗对HPV阳性HNSCC具有更明显的抗肿瘤作用。总体而言，研究结果表明可翻译的基于贵金属的协同治疗在肿瘤治疗中的潜在临床意义。