Abstract Due to their capability of fabricating geometrically complex structures, additive manufacturing (AM) techniques have provided unprecedented opportunities to produce biodegradable metallic implants—especially using Mg alloys, which exhibit appropriate mechanical properties and outstanding biocompatibility. However, many challenges hinder the fabrication of AM-processed biodegradable Mg-based implants, such as the difficulty of Mg powder preparation, powder splash, and crack formation during the AM process. In the present work, the challenges of AM-processed Mg components are analyzed and solutions to these challenges are proposed. A novel Mg-based alloy (Mg–Nd–Zn–Zr alloy, JDBM) powder with a smooth surface and good roundness was first synthesized successfully, and the AM parameters for Mg-based alloys were optimized. Based on the optimized parameters, porous JDBM scaffolds with three different architectures (biomimetic, diamond, and gyroid) were then fabricated by selective laser melting (SLM), and their mechanical properties and degradation behavior were evaluated. Finally, the gyroid scaffolds with the best performance were selected for dicalcium phosphate dihydrate (DCPD) coating treatment, which greatly suppressed the degradation rate and increased the cytocompatibility, indicating a promising prospect for clinical application as bone tissue engineering scaffolds.

中文翻译：

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可生物降解镁植入物增材制造的挑战和解决方案

摘要 由于具有制造几何复杂结构的能力，增材制造 (AM) 技术为生产可生物降解的金属植入物提供了前所未有的机会，尤其是使用具有适当机械性能和出色生物相容性的镁合金。然而，许多挑战阻碍了增材制造加工的可生物降解镁基植入物的制造，例如镁粉制备困难、粉末飞溅和增材制造过程中的裂纹形成。在目前的工作中，分析了 AM 加工镁组件的挑战，并提出了这些挑战的解决方案。首次成功合成了一种表面光滑、圆度好的新型镁基合金（Mg-Nd-Zn-Zr 合金，JDBM）粉末，并对镁基合金的增材制造参数进行了优化。基于优化后的参数，采用选择性激光熔化 (SLM) 方法制备了具有三种不同结构（仿生、金刚石和陀螺）的多孔 JDBM 支架，并评估了它们的机械性能和降解行为。最后，选择性能最佳的陀螺支架进行二水磷酸氢钙（DCPD）涂层处理，大大抑制了降解速率并增加了细胞相容性，表明作为骨组织工程支架的临床应用前景广阔。