A microreactor based continuous inverse suspension polymerization method for synthesis of uniform spherical polyacrylamide (PAM) hydrogel beads is reported. Aqueous phase containing monomer, cross-linker and initiator was dispersed in the form of droplets into a carrier phase (dodecane) by using a microfluidic T-junction. The residence time for the reaction was provided by a microbore tube connected to the T-junction. The effects of factors such as O/A ratio (ratio of the volumetric flow rates of the organic carrier phase and the aqueous phase), microbore tube diameter, design of the microfluidic junction and monomer concentration on the shape, size and uniformity of the beads formed were studied in detail. Two different mixing approaches – in-situ mixing and ex-situ mixing – were also compared. The size of the beads could be varied by changing the O/A ratio. The design of the microfluidic junction and the diameter of the residence time element were found to have significant effect on the size and shape of the beads. Spherical and monodispersed (polydispersity index < 10 %) PAM hydrogel beads could be synthesized by using the microreactor comprising 800 μm diameter microfluidic T-junction as the dispersing device followed by a microbore tube serving as the residence time element.

报道了一种基于微反应器的连续逆悬浮聚合法，用于合成均匀的球形聚丙烯酰胺（PAM）水凝胶珠。通过使用微流体T型接头，将包含单体，交联剂和引发剂的水相以液滴的形式分散到载体相（十二烷）中。反应的停留时间由连接至T型接头的微孔管提供。O / A之比（有机载体相和水相的体积流量之比），微孔管直径，微流体连接设计和单体浓度等因素对微珠形状，尺寸和均匀度的影响形成的细节进行了研究。还比较了两种不同的混合方法-原位混合和异位混合。珠的尺寸可以通过改变O / A比来改变。发现微流体连接的设计和停留时间元件的直径对珠子的尺寸和形状具有显着影响。球形和单分散（多分散性指数<10％）的PAM水凝胶珠可以通过使用直径为800μm的微流体T型结的微反应器作为分散装置，然后使用微孔管作为停留时间元素来合成。