Abstract Some new types of Ce3+ and Dy3+ co-doped manganese-zinc nanospinel ferrites (CDMZNSFs) of the form (Mn0.5Zn0.5)[Fe2-2xCexDyx]O4 (with 0.0 ≤ x ≤ 0.1) were sonochemically produced and characterized. The structure, morphology, optical and magnetic properties of these NSFs were determined as a function of co-dopant (Ce3+ and Dy3+) contents. The direct optical band gap energies of the studied NSFs were ranged from 1.54 to 1.85 eV. The measurements of magnetization versus magnetic field of the prepared NSFs disclosed a superparamagnetic (SPM) behavior at room temperature (RT). The measurements of temperature-dependent magnetizations revealed a transition from superparamagnetic (SPM) state above blocking temperature TB to a ferromagnetic (FM) state below TB. The saturation magnetization and TB decreased with the increase in co-dopant contents. In addition, the bactericidal (on the gram-positive and gram-negative bacterial strains) and anti-cancerous effectiveness of these NSFs were assessed. The cancer cells' growth inhibitory action of these NSFs was tested against both normal (HEK-293) and cancerous (HCT-116) human cells. After 48 h of treatment of the cancerous cells with the NSFs, their population was significantly dropped as shown by the MTT assay, indicating the selective inhibition of the cancer cells growth by the proposed NSFs. Conversely, the non-cancerous cells (HEK-293) population remained unaffected. The IC50 values of the NSFs-treated cancerous cells (HCT-116) were in the range of 0.74-2.35 µg/mL. The results of the MIC and MBC assays revealed the reasonable antibacterial efficacy (growth inhibitory activity) of these NSFs when tested against the E. coli and S. aureus bacterial strains. It is established that the proposed Ce3+/Dy3+ co-activated CDMZNSFs may be beneficial for the anti-cancerous and bactericidal applications.

中文翻译：

---

声化学法制备的 Ce3+/Dy3+ 共活化 Mn-Zn 纳米尖晶石铁氧体的磁性、抗癌和抗菌效果

摘要 采用声化学方法制备并表征了一些新型 Ce3+ 和 Dy3+ 共掺杂锰锌纳米尖晶石铁氧体 (CDMZNSFs)，其形式为 (Mn0.5Zn0.5)[Fe2-2xCexDyx]O4（0.0 ≤ x ≤ 0.1）。这些 NSF 的结构、形态、光学和磁性特性被确定为共掺杂剂（Ce3+ 和 Dy3+）含量的函数。所研究的 NSF 的直接光学带隙能量范围为 1.54 至 1.85 eV。制备的 NSF 的磁化强度与磁场的测量结果揭示了室温 (RT) 下的超顺磁性 (SPM) 行为。温度相关磁化强度的测量结果表明，从高于阻塞温度 TB 的超顺磁性 (SPM) 状态转变为低于 TB 的铁磁 (FM) 状态。饱和磁化强度和 TB 随着共掺杂剂含量的增加而降低。此外，还评估了这些 NSF 的杀菌（对革兰氏阳性和革兰氏阴性菌株）和抗癌效力。针对正常（HEK-293）和癌性（HCT-116）人类细胞测试了这些NSF的癌细胞生长抑制作用。用 NSF 处理癌细胞 48 小时后，如 MTT 测定所示，它们的数量显着下降，表明提议的 NSF 选择性抑制了癌细胞的生长。相反，非癌细胞 (HEK-293) 群体保持不受影响。NSFs 处理的癌细胞 (HCT-116) 的 IC50 值在 0.74-2.35 µg/mL 的范围内。MIC 和 MBC 测定的结果揭示了这些 NSF 在针对大肠杆菌和金黄色葡萄球菌进行测试时具有合理的抗菌功效（生长抑制活性）。金黄色葡萄球菌菌株。已经确定，所提出的 Ce3+/Dy3+ 共激活 CDMZNSFs 可能有益于抗癌和杀菌应用。