The active and passive mechanical behavior of a cosmetic tightening product for skin anti-aging is investigated based on a wide range of in vivo and in vitro measurements. The experimental data are used to inform a numerical model of the attained cosmetic effect, which is then implemented in a commercial finite-element framework and used to analyze the mechanisms that regulate the biomechanical interaction between the native tissue and the tightening film. Such a film reduces wrinkles and enhances skin consistency by increasing its stiffness by 48-107% and reducing inelastic, non-recoverable deformations (−47%). The substrate deformability influences both the extent of tightening and the reduction of wrinkle amplitude. The present findings allow, for the first time, to rationalize the mechanisms of action of cosmetic products with a tightening action and provide quantitative evidence for further optimization of this fascinating class of biomaterials.

基于多种体内和体外研究了用于皮肤抗衰老的化妆品紧肤产品的主动和被动机械性能测量。实验数据用于告知获得的美容效果的数值模型，然后在商业有限元框架中实施该模型，并用于分析调节天然组织和绷紧膜之间生物力学相互作用的机制。此类薄膜可通过将其刚度提高48-107％并减少无弹性，不可恢复的变形（-47％）来减少皱纹并增强皮肤一致性。基材的变形性会影响收紧程度和皱纹幅度的减少。本发现首次使具有紧缩作用的化妆品的作用机理合理化，并为进一步优化这种引人入胜的生物材料类别提供了定量证据。