Acta Biomaterialia ( IF 9.4 ) Pub Date : 2020-08-25 , DOI: 10.1016/j.actbio.2020.08.023 Tikai Zhang 1 , Bin Sun 2 , Jiangna Guo 1 , Mengyao Wang 1 , Hengqing Cui 2 , Hailei Mao 3 , Bin Wang 4 , Feng Yan 5
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As an inflammatory skin disease of pilosebaceous follicles, Propionibacterium acnes (P. acnes) can aggravate local inflammatory responses and forms acne lesions. However, due to the skin barrier, various transdermal measures other than antibiotic creams are necessary. Microneedle (MN) patches are emerging platforms for the transdermal delivery of various therapeutics since it can effectively create transport pathways in the epidermis. Herein, we develop an active pharmaceutical ingredient poly(ionic liquid) (API PIL)-based MN patches containing salicylic acid (SA). The PIL-based MNs are simply prepared through photo-crosslinking of an imidazolium-type ionic liquid (IL) monomer in MN micro-molds, and following by anion exchange with salicylic acid anions (SA−). The fabricated SA-loaded PIL-MNs exhibited therapeutic efficiency in the topical treatment of P. acnes infection in vitro and in vivo. These active pharmaceutical ingredient PIL-based MNs can improve acne treatment, demonstrating potential applications for skin diseases.
Statement of Significance
Microneedle (MN) patches can be used as platforms for transdermal delivery of various therapeutics to treat bacterial infection. Here, a facile strategy was developed to synthesize active pharmaceutical ingredient poly(ionic liquid)-based microneedle patches by anion-exchange with salicylic acid anion (SA−). The fabricated SA-loaded PIL-MNs are active on not only anti-bacteria but also anti-inflammation in P. acnes treated mice, and may have potential applications for skin acne infection.
中文翻译：
活性药物成分聚（离子液体）基微针，用于治疗皮肤痤疮感染。
痤疮丙酸杆菌（痤疮丙酸杆菌）作为一种毛囊状毛囊的炎性皮肤病，可加剧局部炎症反应并形成痤疮病变。但是，由于皮肤屏障的缘故，除了抗生素乳膏外，还需要各种透皮措施。微针（MN）贴剂是可以透皮递送各种治疗剂的新兴平台，因为它可以有效地在表皮中创建转运途径。在本文中，我们开发了基于活性药物成分的聚（离子液体）（API PIL）基的MN贴剂，其中含有水杨酸（SA）。基于PIL-MN的简单地通过光交联的咪唑鎓型离子液体（IL）在MN微模单体，并通过与水杨酸根阴离子的阴离子交换以下（SA制备-）。在体外和体内局部治疗痤疮丙酸杆菌感染时，制备的SA-负载的PIL-MNs显示出治疗效果。这些基于药物活性成分PIL的MN可以改善痤疮的治疗，证明其在皮肤疾病中的潜在应用。
重要声明
可以将微针（MN）贴片用作各种疗法的经皮输送平台，以治疗细菌感染。在这里，一个浅显的策略的开发是为了合成活性药物成分的聚（离子性液体）通过与水杨酸根阴离子（SA阴离子交换为基础的微针贴片- ）。制备的SA加载的PIL-MNs不仅对痤疮丙酸杆菌治疗的小鼠具有抗菌作用，而且还具有抗发炎作用，并且可能具有潜在的皮肤痤疮感染用途。
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