Purpose

The objective of our meta-analysis was to estimate the effect of VTS on obstetric outcomes of ART singletons.

Methods

PubMed, Embase, MEDLINE, and ClinicalTrials.gov were searched up to January 2019 to find studies reporting the obstetric outcomes of ART singletons with VTS. Dichotomous data were expressed as odds ratios (OR) with 95% confidence intervals (CI). Continuous data were expressed as weighted mean difference (WMD) with 95% CI.

Results

A total of 17 observational studies encompassing more than 60,000 ART singletons were included in this meta-analysis. The impact of VTS on singletons was highly dependent on the definition of VTS, precisely, the vanishing timing and intrauterine growth stage. When VTS happened at or before 14 weeks, regardless of intrauterine growth stage, there were no differences in terms of gestational age (GA) [WMD = − 0.08, 95% CI = − 0.27, 0.10], preterm birth (< 37 weeks) (PTB) [OR = 1.23, 95% CI = 0.89, 1.70], and low birth weight (< 2.5 kg) (LBW) [OR = 1.56, 95% CI = 1.00, 2.43] in original singletons versus singleton with VTS. On the contrary, VTS occurred after 14 weeks was associated with significantly shorter GW and lower BW, as well as higher risks of PTB and LBW. When the sac reduced in VTS was an empty gestational sac, there would be no differences in GW, PTB, and LBW between singletons versus singletons with VTS, whereas the loss of a fetus with cardiac-activity was associated with adverse obstetric outcomes.

Conclusions

This meta-analysis suggests whether or not VTS is harmful to obstetric outcomes is highly dependent on the vanishing timing and intrauterine growth stage.

中文翻译：

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双胞胎消失综合征是否与 ART 单胎的不良产科结果有关？系统评价和荟萃分析。

目的

我们荟萃分析的目的是评估 VTS 对 ART 单胎产科结果的影响。

方法

对 PubMed、Embase、MEDLINE 和 ClinicalTrials.gov 进行了搜索，直至 2019 年 1 月，以查找报告 ART 单胎与 VTS 的产科结果的研究。二分类数据表示为优势比 (OR) 和 95% 置信区间 (CI)。连续数据表示为具有 95% CI 的加权平均差 (WMD)。

结果

该荟萃分析共纳入了 17 项观察性研究，涉及 60,000 多名 ART 单身人士。VTS 对单胎的影响高度依赖于 VTS 的定义，准确地说，是消失时间和宫内生长阶段。当 VTS 发生在 14 周或之前，无论宫内生长阶段如何，在胎龄 (GA) [WMD = − 0.08, 95% CI = − 0.27, 0.10]、早产（< 37 周）方面没有差异(PTB) [OR = 1.23, 95% CI = 0.89, 1.70] 和低出生体重 (< 2.5 kg) (LBW) [OR = 1.56, 95% CI = 1.00, 2.43] 原始单胎与 VTS 单胎。相反，14 周后发生的 VTS 与显着更短的 GW 和更低的 BW 以及更高的 PTB 和 LBW 风险相关。当 VTS 中减少的囊是一个空的妊娠囊时，

结论

这项荟萃分析表明 VTS 是否对产科结果有害在很大程度上取决于消失时间和宫内生长阶段。