Copper-catalyzed 1,1-alkynylalkylation of alkynes: access toward conjugated enynes,Organic Chemistry Frontiers

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Copper-catalyzed 1,1-alkynylalkylation of alkynes: access toward conjugated enynes
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-08-24 , DOI: 10.1039/d0qo00826e
Y. Lv _{1,

2,

3,

4} , Y. Wang _{1,

2,

3,

4} , W. Pu _{1,

2,

3,

4} , X. Zhu _{4,

5,

6,

7} , N. Wu _{1,

2,

3,

4} , Y. Zhao _{1,

2,

3,

4}

Affiliation

A copper-catalyzed 1,1-alkynylalkylation of alkynes with α-haloacetamides is realized. This reaction provides a practical and simple synthetic methodology for various conjugated enynes with excellent functional group compatibility and high stereo- and regioselectivity. The mechanism of the tandem copper-catalyzed Sonogashira coupling reaction and syn-alkynylcupration of allenamides has been investigated.

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