Transition metal-free synthesis of 3-trifluoromethyl chromones via tandem C–H trifluoromethylation and chromone annulation of enaminones,Organic Chemistry Frontiers

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Transition metal-free synthesis of 3-trifluoromethyl chromones via tandem C–H trifluoromethylation and chromone annulation of enaminones
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-08-24 , DOI: 10.1039/d0qo00855a
Qing Yu _{1,

2,

3,

4} , Yunyun Liu _{1,

2,

3,

4} , Jie-Ping Wan _{1,

2,

3,

4}

Affiliation

The tandem C–H bond trifluoromethylation and chromone annulation reactions of o-hydroxyphenyl enaminones have been realized for the practical synthesis of 3-trifluoromethyl chromones. The reactions are performed efficiently with the promotion of K₂S₂O₈ without using any transition metal catalyst or additive. In addition, the 3-trifluoromethyl chromone products have been successfully used for the synthesis of 3-trifluoromethyl pyrimidines by reacting with guanidine/amidine substrates.

中文翻译：

串联C–H三氟甲基化和烯胺酮的色酮环化反应，无需过渡金属即可合成3-三氟甲基色酮

邻位羟基苯基烯胺酮的串联C–H键三氟甲基化和色酮环化反应已经实现了3-三氟甲基色酮的实际合成。在不使用任何过渡金属催化剂或添加剂的情况下，在促进K ₂ S ₂ O _8的条件下有效地进行了反应。另外，通过与胍/ am底物反应，3-三氟甲基色酮产物已成功用于3-三氟甲基嘧啶的合成。

更新日期：2020-09-16

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