Abstract: Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune myopathy characterized by severe diffuse proximal myofiber necrosis in the context of inflammatory myopathy. Autoantibodies of anti-signal recognition particle and anti-hydroxy-3-methylglutaryl-CoA reductase are two antibodies specific to IMNM. Erythema nodosum (EN) is often accompanied by various systemic diseases, such as autoimmune diseases. Herein, we report a female patient with signal recognition particle-associated IMNM, with EN as the first presentation. She showed significant clinical improvement after the initiation of glucocorticoids, intravenous immunoglobulin, rituximab, and mycophenolate mofetil. This case indicates that IMNM can initially present as EN. IMNM and EN might have overlapping pathogeneses.

Keywords: immune-mediated necrotizing myopathy, erythema nodosum, autoantibody


中文翻译：

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免疫介导的坏死性肌病，最初表现为结节性红斑。

摘要：免疫介导的坏死性肌病（IMNM）是一种自身免疫性肌病，其特征是在炎性肌病的情况下严重弥漫性近端肌纤维坏死。抗信号识别颗粒的自身抗体和抗羟基-3-甲基戊二酰辅酶A还原酶是针对IMNM的两种抗体。结节性红斑（EN）通常伴有多种全身性疾病，例如自身免疫性疾病。在本文中，我们报道了一名女性患者，该患者患有信号识别颗粒相关的IMNM，其中EN首次出现。在开始使用糖皮质激素，静脉注射免疫球蛋白，利妥昔单抗和霉酚酸酯后，她表现出明显的临床改善。这种情况表明IMNM最初可以表示为EN。IMNM和EN可能具有重叠的病原体。

关键字： 免疫介导的坏死性肌病，结节性红斑，自身抗体