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Casein Hydrolysate Containing Milk-Derived Peptides Reduces Facial Pigmentation Partly by Decreasing Advanced Glycation End Products in the Skin: A Randomized Double-Blind Placebo-Controlled Trial
Rejuvenation Research ( IF 2.2 ) Pub Date : 2021-04-19 , DOI: 10.1089/rej.2020.2343
Michiya Igase 1, 2 , Yoko Okada 1, 2 , Keiji Igase 3 , Sayaka Matsumoto 2 , Kensuke Senzaki 2 , Masayuki Ochi 2 , Yasumasa Ohyagi 2 , Sho-Ichi Yamagishi 4
Affiliation  

Casein hydrolysate has been shown to improve arterial stiffness as estimated by brachial-ankle pulse wave velocity (baPWV) in untreated hypertensive patients. Facial pigmentation is associated with atherosclerosis, both of which are supposed to be modulated by tissue accumulation of advanced glycation end products (AGEs). However, effects of casein hydrolysate on facial pigmentation and AGEs remain largely unknown. This randomized double-blind placebo-controlled trial evaluated whether and how casein hydrolysate improves facial pigmentation in 80 nonhypertensive Japanese patients. Study participants were randomly assigned to receive either active tablets containing casein hydrolysate or placebo for 48 weeks. Facial pigmentation area, baPWV, and skin accumulation levels of AGEs were evaluated by Robo Skin Analyzer RSA50S II, volume–plethysmographic apparatus, and AGE Reader, respectively, at baseline and at the end of the intervention. Treatment with casein hydrolysate, but not placebo significantly reduced triglycerides and facial pigmentation area. There were significant differences of changes in triglycerides, facial pigmentation area, skin accumulation levels of AGEs, and baPWV between the two groups. Furthermore, changes in triglycerides and skin accumulation levels of AGEs were positively and independently associated with those in facial pigmentation area, whereas changes in baPWV were not. This study suggests that casein hydrolysate reduces facial pigmentation area in nonhypertensive participants partly by decreasing skin accumulation levels of AGEs. Clinical-Trials.gov ID: UMIN000027675.

中文翻译:

含有牛奶衍生肽的酪蛋白水解物通过减少皮肤中的高级糖化终产物来部分减少面部色素沉着:一项随机双盲安慰剂对照试验

酪蛋白水解物已被证明可以改善未经治疗的高血压患者的臂踝脉搏波速度 (baPWV) 估计的动脉僵硬度。面部色素沉着与动脉粥样硬化有关,这两者都被认为是由晚期糖基化终产物 (AGEs) 的组织积累所调节的。然而,酪蛋白水解物对面部色素沉着和 AGEs 的影响在很大程度上仍然未知。这项随机双盲安慰剂对照试验评估了酪蛋白水解物是否以及如何改善 80 名日本非高血压患者的面部色素沉着。研究参与者被随机分配接受含有酪蛋白水解物的活性药片或安慰剂,为期 48 周。面部色素沉着面积、baPWV 和 AGEs 的皮肤积累水平由 Robo Skin Analyzer RSA50S II 评估,体积体积描记仪和 AGE Reader,分别在基线和干预结束时。用酪蛋白水解物(而非安慰剂)治疗可显着降低甘油三酯和面部色素沉着区域。两组间甘油三酯、面部色素沉着面积、AGEs皮肤蓄积水平、baPWV变化均存在显着差异。此外,甘油三酯和AGEs皮肤积累水平的变化与面部色素沉着区域的变化呈正相关且独立相关,而baPWV的变化则不然。这项研究表明,酪蛋白水解物减少了非高血压参与者的面部色素沉着区域,部分原因是降低了 AGEs 的皮肤积累水平。Clinical-Trials.gov ID:UMIN000027675。在基线和干预结束时。用酪蛋白水解物(而非安慰剂)治疗可显着降低甘油三酯和面部色素沉着区域。两组间甘油三酯、面部色素沉着面积、AGEs皮肤蓄积水平、baPWV变化均存在显着差异。此外,甘油三酯和AGEs皮肤积累水平的变化与面部色素沉着区域的变化呈正相关且独立相关,而baPWV的变化则不然。这项研究表明,酪蛋白水解物减少了非高血压参与者的面部色素沉着区域,部分原因是降低了 AGEs 的皮肤积累水平。Clinical-Trials.gov ID:UMIN000027675。在基线和干预结束时。用酪蛋白水解物(而非安慰剂)治疗可显着降低甘油三酯和面部色素沉着区域。两组间甘油三酯、面部色素沉着面积、AGEs皮肤蓄积水平、baPWV变化均存在显着差异。此外,甘油三酯和AGEs皮肤积累水平的变化与面部色素沉着区域的变化呈正相关且独立相关,而baPWV的变化则不然。这项研究表明,酪蛋白水解物减少了非高血压参与者的面部色素沉着区域,部分原因是降低了 AGEs 的皮肤积累水平。Clinical-Trials.gov ID:UMIN000027675。两组间甘油三酯、面部色素沉着面积、AGEs皮肤蓄积水平、baPWV变化均存在显着差异。此外,甘油三酯和AGEs皮肤积累水平的变化与面部色素沉着区域的变化呈正相关且独立相关,而baPWV的变化则不然。这项研究表明,酪蛋白水解物减少了非高血压参与者的面部色素沉着区域,部分原因是降低了 AGEs 的皮肤积累水平。Clinical-Trials.gov ID:UMIN000027675。两组间甘油三酯、面部色素沉着面积、AGEs皮肤蓄积水平、baPWV变化均存在显着差异。此外,甘油三酯和AGEs皮肤积累水平的变化与面部色素沉着区域的变化呈正相关且独立相关,而baPWV的变化则不然。这项研究表明,酪蛋白水解物减少了非高血压参与者的面部色素沉着区域,部分原因是降低了 AGEs 的皮肤积累水平。Clinical-Trials.gov ID:UMIN000027675。甘油三酯的变化和AGEs的皮肤积累水平与面部色素沉着区域的变化呈正相关且独立相关,而baPWV的变化则不然。这项研究表明,酪蛋白水解物减少了非高血压参与者的面部色素沉着区域,部分原因是降低了 AGEs 的皮肤积累水平。Clinical-Trials.gov ID:UMIN000027675。甘油三酯的变化和AGEs的皮肤积累水平与面部色素沉着区域的变化呈正相关且独立相关,而baPWV的变化则不然。这项研究表明,酪蛋白水解物减少了非高血压参与者的面部色素沉着区域,部分原因是降低了 AGEs 的皮肤积累水平。Clinical-Trials.gov ID:UMIN000027675。
更新日期:2021-04-20
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