Supplemental Digital Content is available in the text. Renal sympathetic denervation, a potentially revolutionary interventional treatment for hypertension, faces an existential problem due to the inability to confirm successful ablation of the targeted renal sympathetic nerves. Based on the observation that renal sympathetic nerve activity exerts rhythmic, baroreflex-driven, and vasoconstrictive control of the renal vasculature, we developed a novel technique for identifying rhythmic sympathetic vascular control using a time-varying, 2-component Windkessel model of the renal circulation. This technology was tested in 2 different animal models of renal denervation; 10 rabbits underwent chronic, surgical renal denervation, and 9 pigs underwent acute, functional renal denervation via intrathecal administration of ropivacaine. Both methods of renal denervation reduced negative admittance gain, negative phase shift renal vascular control at known sympathetic vasomotor frequencies, consistent with a reduction in vasoconstrictive, baroreflex-driven renal sympathetic vasomotion. Classic measures like mean renal blood flow and mean renal vascular resistance were not significantly affected in either model of renal denervation. Renal sympathetic vasomotion monitoring could provide intraprocedural feedback for interventionists performing renal denervation and serve more broadly as a platform technology for the evaluation and treatment of diseases affecting the sympathetic nervous system.

中文翻译：

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肾交感神经血管舒缩的量化作为肾去神经支配的新终点

补充数字内容在文本中可用。肾交感神经去神经支配术是一种潜在的革命性高血压介入治疗，由于无法确认靶向肾交感神经的成功消融，因此面临着生存问题。基于对肾交感神经活动对肾血管系统施加节律性、压力反射驱动和血管收缩控制的观察，我们开发了一种新技术，用于使用肾循环的时变 2 分量 Windkessel 模型识别节律性交感神经血管控制. 该技术在 2 种不同的肾去神经支配动物模型中进行了测试；10 只兔子接受了慢性肾去神经支配术，9 只猪通过鞘内注射罗哌卡因接受了急性、功能性肾去神经支配术。肾去神经支配的两种方法都减少了负导纳增益，在已知的交感神经血管舒缩频率下负相移肾血管控制，与血管收缩、压力反射驱动的肾交感神经血管舒缩的减少一致。在肾去神经支配的任一模型中，诸如平均肾血流量和平均肾血管阻力之类的经典测量均未受到显着影响。肾交感神经血管舒缩监测可以为进行肾去神经支配的干预者提供术中反馈，并更广泛地作为评估和治疗影响交感神经系统疾病的平台技术。压力反射驱动的肾交感神经血管舒缩。在肾去神经支配的任一模型中，诸如平均肾血流量和平均肾血管阻力之类的经典测量均未受到显着影响。肾交感神经血管舒缩监测可以为进行肾去神经支配的干预者提供术中反馈，并更广泛地作为评估和治疗影响交感神经系统疾病的平台技术。压力反射驱动的肾交感神经血管舒缩。在肾去神经支配的任一模型中，诸如平均肾血流量和平均肾血管阻力之类的经典测量均未受到显着影响。肾交感神经血管舒缩监测可以为进行肾去神经支配的干预者提供术中反馈，并更广泛地作为评估和治疗影响交感神经系统疾病的平台技术。