Rotenone is a widely used organic pesticide; its serious side effect for off‐target species is neurotoxicity. The primary mechanism of rotenone toxicity is inhibition of the mitochondrial complex I. Oxidative stress, apoptosis, and reduction of autophagy are key outcomes of the inhibition of complex I. Numerous in vitro and in vivo studies have shown antioxidant, anti‐apoptotic, and autophagy enhancement of a variety of natural compounds (NCs). In this manuscript, we reviewed several NCs, which have protective effects against rotenone‐induced neurotoxicity.

中文翻译：

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天然化合物对鱼藤酮诱导的神经毒性的保护作用。

鱼藤酮是一种广泛使用的有机农药。它对脱靶物种的严重副作用是神经毒性。鱼藤酮毒性的主要机理是抑制线粒体复合物I。氧化应激，细胞凋亡和自噬减少是复合物I抑制的关键结果。大量的体内和体外研究表明抗氧化剂，抗凋亡和自噬增强多种天然化合物（NC）。在本文中，我们回顾了几种NC，它们对鱼藤酮诱导的神经毒性具有保护作用。