Donor genetic backgrounds contribute to the functional heterogeneity of stem cells and clinical outcomes.,STEM CELLS Translational Medicine

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Donor genetic backgrounds contribute to the functional heterogeneity of stem cells and clinical outcomes.
STEM CELLS Translational Medicine ( IF 5.4 ) Pub Date : 2020-08-24 , DOI: 10.1002/sctm.20-0155
Ting Wang ₁ , Juan Zhang _{1,

2} , Jinqi Liao ₃ , Fan Zhang ₄ , Guangqian Zhou ₁

Affiliation

Stable and sustainable stem cell sources for stem cell‐based therapies are scarce and a key bottleneck for clinical applications. The regenerative potential of stem cells is usually attributed to several allogeneic or even autologous donor‐related factors. Genetic background and epigenetic variations in different individuals may significantly affect the functional heterogeneity of stem cells. Particularly, single‐nucleotide polymorphisms (SNPs) have been implicated in diseases with monogenetic or multifactorial and complex genetic etiologies. However, the possible effects of individual SNPs on donor stem cells remain far from fully elucidated. In this Perspective, we will discuss the roles played by donor genetic traits in the functional heterogeneity of induced pluripotent stem cells, mesenchymal stem cells, and hematopoietic stem cells and their implications for regenerative medicine and therapy.

中文翻译：

供体遗传背景有助于干细胞的功能异质性和临床结果。

用于干细胞疗法的稳定和可持续的干细胞来源稀缺，并且是临床应用的关键瓶颈。干细胞的再生潜力通常归因于几种同种异体甚至自体供体相关因素。不同个体的遗传背景和表观遗传变异可能显着影响干细胞的功能异质性。特别是，单核苷酸多态性 (SNP) 与具有单基因或多因素和复杂遗传病因的疾病有关。然而，个体 SNP 对供体干细胞的可能影响仍远未完全阐明。在这个视角中，我们将讨论供体遗传特征在诱导多能干细胞、间充质干细胞、

更新日期：2020-08-24

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