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Social distance teaching and learning: An online DNA nucleotide binding lab experience for health sciences and non‐major students
Biochemistry and Molecular Biology Education ( IF 1.2 ) Pub Date : 2020-08-24 , DOI: 10.1002/bmb.21426
Angela L Mahaffey 1
Affiliation  

DNA analysis is a common diagnostic tool in healthcare: ranging from microbial typing (e.g. DNA strands of viral, bacterial and even fungal pathogens), oncological screen (e.g. Breast cancer detection via DNA analysis of any BRCA gene mutations), genetic amniocentesis test (a medical technique used in determining chromosomal conditions such as down syndrome in the fetus) and a host of other medical diagnostics based on the knowledge of deoxyribonucleic acid (DNA) and the genetic information carried in this macromolecule. However, such a wide‐range of medical diagnostic mechanisms using DNA begs the question: How much does the undergraduate health sciences and/or non‐major students understand about the basic biochemical properties of DNA? Here, a virtual lab module was used (with the addition of Pre and Post Lab Questions and a Discussion Topic relating DNA to Healthcare) along with a learning management system, to help undergraduate health sciences students visualize the biochemical properties of DNA molecule, such as binding constant and Gibbs free energy of binding. This lab was adapted to offer a platform on which an Instructor can design steps for students to explore the DNA nucleotide binding module during a time in which social distance curricula is necessary.

中文翻译:

社交远程教学:面向健康科学和非专业学生的在线 DNA 核苷酸结合实验室体验

DNA 分析是医疗保健中的一种常见诊断工具:从微生物分型(例如病毒、细菌甚至真菌病原体的 DNA 链)、肿瘤筛查(例如通过对任何 BRCA 基因突变的 DNA 分析进行的乳腺癌检测)、基因羊膜穿刺术测试(一种用于确定染色体状况(如胎儿唐氏综合症)的医学技术,以及基于脱氧核糖核酸 (DNA) 知识和该大分子中携带的遗传信息的许多其他医学诊断方法。然而,如此广泛的使用 DNA 的医学诊断机制引出了一个问题:本科健康科学和/或非专业学生对 DNA 的基本生化特性了解多少?这里,使用了一个虚拟实验室模块(增加了实验室前后问题以及与 DNA 与医疗保健相关的讨论主题)以及一个学习管理系统,以帮助本科健康科学专业的学生可视化 DNA 分子的生化特性,例如结合常数和吉布斯结合自由能。该实验室提供了一个平台,教师可以在该平台上设计步骤,让学生在需要社交距离课程的时候探索 DNA 核苷酸结合模块。
更新日期:2020-08-24
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