N−H and C−H Functionalization of Sulfoximine: Recent Advancement and Prospects,Asian Journal of Organic Chemistry

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N−H and C−H Functionalization of Sulfoximine: Recent Advancement and Prospects
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-08-24 , DOI: 10.1002/ajoc.202000320
prasanjit ghosh ₁ , Bhaskar Ganguly ₂ , Sajal Das ₂

Affiliation

Sulfoximine and its congeners are a versatile class of structural motifs widely found in a plethora of pharmaceutical compounds and crop protection industries due to their fascinating structural architecture. Former discoveries nicely demonstrates the synthetic routes of unmasked and various N‐functionalized sulfoximines but recent efforts from the synthetic community have divulged the applicability of sulfoximine analogue as reusable and transformable DG (directing group) to fabricate multifunctionalized (Het)arenes and enhance the bioactivities. Considering the synthetic potentiality and great influence of this scaffold, we provide a summary of N−H/C−H functionalization strategies of sulfoximine and application (as a directing group) with special emphasis on the mechanistic underpinnings. Additionally, we also hoped that this comprehensive review article (up to midst of 2020) will be useful for synthetic researchers and medicinal chemists and will inspire for further novel chemical transformations in this arena.

中文翻译：

磺胺嘧啶的NH和CH功能化：最新进展和前景

磺胺嘧啶及其同类物是一类通用的结构基序，由于其引人入胜的结构构造，在众多药物化合物和农作物保护行业中广泛发现。以前的发现很好地证明了未掩盖的和各种N功能化的亚砜亚胺的合成路线，但合成界的最新努力揭示了亚砜亚胺类似物作为可重复使用和可转化的DG（指导组）的适用性，以制造多功能的（Het）芳烃并增强生物活性。考虑到该支架的合成潜力和巨大影响，我们提供了亚砜亚胺的NH-CH功能官能化策略及其应用（作为指导小组）的摘要，特别强调了机械基础。另外，

更新日期：2020-08-24

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