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PhotoPROTACs: A Novel Biotechnology for Cancer Treatment.
Trends in Cell Biology ( IF 13.0 ) Pub Date : 2020-08-24 , DOI: 10.1016/j.tcb.2020.08.003
Zhi-Wei Wang 1 , Yi Liu 2 , Xueqiong Zhu 3
Affiliation  

PROteolysis-TArgeting Chimeras (PROTACs) have been developed for targeting specific protein destruction. Two recent studies in Science Advances by Liu et al. and Reynders et al. reported a novel technology, PHOtochemically TArgeting Chimeras (PHOTACs) or opto-PROTAC, which is light-induced control of protein degradation. This new approach might lead to precision therapeutics in patients with cancer.



中文翻译:

PhotoPROTAC:一种用于癌症治疗的新型生物技术。

已开发出蛋白水解嵌合体(PROTAC)以靶向特异性蛋白质破坏。Liu等人最近在《科学进展》中进行了两项研究和Reynders等。报道了一种新技术,即光化学性靶嵌合体(PHOTAC)或光PROTAC,它是光诱导的蛋白质降解控制。这种新方法可能会导致癌症患者的精确治疗。

更新日期:2020-09-24
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