Hallmark mutations in WNT and SHH medulloblastoma are usually distinct, but DDX3X is often mutated in both subgroups. In this issue of Developmental Cell, Patmore et al. identify Ddx3x as essential for hindbrain patterning, cell fate determination, and as a tumor suppressor gene that restricts cell lineage progression in tumorigenesis.

中文翻译：

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后脑的建筑师：DDX3X规范正常和恶性的发展。

WNT和SHH髓母细胞瘤中的标志性突变通常是不同的，但DDX3X经常在两个亚组中发生突变。在此期《发育细胞》中，Patmore等人。将Ddx3x鉴定为后脑模式，细胞命运确定所必需的，并且是抑制肿瘤发生中细胞谱系进程的抑癌基因。