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Why Airway Gland Secretions Are Abnormally Sticky in Cystic Fibrosis, and Why Not Much Can Be Done About It.
Developmental Cell ( IF 10.7 ) Pub Date : 2020-08-24 , DOI: 10.1016/j.devcel.2020.07.008 Jonathan H Widdicombe 1
中文翻译:
为什么气道腺分泌物在囊性纤维化中异常粘滞,为什么不能做得太多。
更新日期:2020-08-24
Developmental Cell ( IF 10.7 ) Pub Date : 2020-08-24 , DOI: 10.1016/j.devcel.2020.07.008 Jonathan H Widdicombe 1
Affiliation
In this issue of Developmental Cell, Xie et al. show that in cystic fibrosis, airway gland mucus gels form under conditions of high acidity and protein concentration. This causes them to be unusually stiff. This abnormal rheology cannot be corrected by changing pH or calcium levels in the bathing medium.
中文翻译:
为什么气道腺分泌物在囊性纤维化中异常粘滞,为什么不能做得太多。
在本期《发育细胞》中,谢等人。表明在囊性纤维化中,在高酸度和高蛋白浓度的条件下会形成气道黏液凝胶。这导致它们异常坚硬。无法通过改变沐浴介质中的pH或钙水平来纠正这种异常的流变性。