The current state-of-the-art experiments in time-resolved structural biology are undoubtedly the recent extremely impressive results that are emerging from XFEL-based experiments. However, there is a large range of macromolecular systems where the biological interest is predominantly in the slower dynamics (μs–s), that produce well diffracting microcrystals, and for which synchrotron-based experiments are extremely well suited. The combination of microfocus X-ray beams and the development of a range of sample delivery platforms has now made routine millisecond time-resolved experiments at microfocus macromolecular crystallography beamlines a real possibility and is driving development of dedicated endstations for time-resolved serial synchrotron crystallography.

当前时间分辨结构生物学中最先进的实验无疑是最近从基于 XFEL 的实验中出现的极其令人印象深刻的结果。然而，有很多大分子系统的生物学兴趣主要集中在较慢的动力学（μs-s）上，它们产生良好的衍射微晶，基于同步加速器的实验非常适合这些系统。微焦点 X 射线束与一系列样品输送平台的开发相结合，现在使微焦点大分子晶体学光束线上的常规毫秒时间分辨实验成为可能，并正在推动时间分辨串行同步加速器晶体学专用终端站的开发。