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Hydrogen Sulfide-Responsive Self-Assembled Nanogel
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2020-08-23 , DOI: 10.1021/acsapm.0c00759 Peng-Hao Hsu 1 , Riku Kawasaki 2 , Keita Yamana 2 , Hinata Isozaki 2 , Shogo Kawamura 2 , Atsushi Ikeda 2 , Adah Almutairi 3
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2020-08-23 , DOI: 10.1021/acsapm.0c00759 Peng-Hao Hsu 1 , Riku Kawasaki 2 , Keita Yamana 2 , Hinata Isozaki 2 , Shogo Kawamura 2 , Atsushi Ikeda 2 , Adah Almutairi 3
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Hydrogen sulfide (H2S) is a signaling molecule whose overexpression is identified in various cancers. Despite the flourishing research of H2S-responsive nanomaterials, the development of H2S-responsive nanogels (NGs) has not been attempted yet. Here we report, for the first time, H2S-responsive NG, which was formulated from H2S-responsive cholesterol-modified dextran (SC-Dex) through self-assembly. H2S induces the dissociation of cholesterols from the dextran backbone of SC-Dex via reduction of aryl azide and the subsequent 1,4-rearrangement. In the presence of H2S, SC-Dex NGs show swelling behavior and controlled release of encapsulated protein. This NG might show potential applications as a H2S-responsive drug delivery system.
中文翻译：
硫化氢响应自组装纳米凝胶
硫化氢（H 2 S）是一种信号分子，在多种癌症中都发现了其过度表达。尽管H的蓬勃发展研究2 S-响应纳米材料，H的发展2 S-响应纳米凝胶（NGS）尚未尝试。在这里，我们首次报告了H 2 S反应性NG，它是通过自组装由H 2 S反应性胆固醇修饰的葡聚糖（SC-Dex）配制而成的。H 2 S通过芳基叠氮化物的还原和随后的1,4-重排诱导胆固醇从SC-Dex的葡聚糖主链上解离。在H 2存在下S，SC-Dex NGs表现出溶胀行为和封装蛋白的受控释放。这种NG可能显示出作为H 2 S反应性药物递送系统的潜在应用。
更新日期：2020-09-11
中文翻译：
硫化氢响应自组装纳米凝胶
硫化氢（H 2 S）是一种信号分子，在多种癌症中都发现了其过度表达。尽管H的蓬勃发展研究2 S-响应纳米材料，H的发展2 S-响应纳米凝胶（NGS）尚未尝试。在这里，我们首次报告了H 2 S反应性NG，它是通过自组装由H 2 S反应性胆固醇修饰的葡聚糖（SC-Dex）配制而成的。H 2 S通过芳基叠氮化物的还原和随后的1,4-重排诱导胆固醇从SC-Dex的葡聚糖主链上解离。在H 2存在下S，SC-Dex NGs表现出溶胀行为和封装蛋白的受控释放。这种NG可能显示出作为H 2 S反应性药物递送系统的潜在应用。
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