Dual Palladium/Scandium Catalysis toward Rotationally Hindered C3‐Naphthylated Indoles from β‐Alkynyl Ketones and o‐Alkynyl Anilines,Chinese Journal of Chemistry

当前位置： X-MOL 学术 › Chin. J. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Dual Palladium/Scandium Catalysis toward Rotationally Hindered C3‐Naphthylated Indoles from β‐Alkynyl Ketones and o‐Alkynyl Anilines
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2020-08-23 , DOI: 10.1002/cjoc.202000304
Dan Wang ₁ , Shi‐Chao Wang ₁ , Wen‐Juan Hao ₁ , Shu‐Jiang Tu ₁ , Bo Jiang ₁

Affiliation

A new dual palladium/scandium catalysis starting from β‐alkynyl ketones and o‐alkynyl anilines is reported for the first time, leading to the atom‐economic synthesis of rotationally hindered C3‐naphthylated indoles in moderate to good yields and high regioselectivity. This method can tolerate normal air conditions, and features the use of palladium/scandium cooperative catalysts without any ligand, facile double annulation involving various internal alkynes, and good functional group tolerance.

中文翻译：

β-炔基酮和邻炔基苯胺对旋转受阻的C3-萘化吲哚的双重钯/ Scan催化

首次报道了从β-炔基酮和邻炔基苯胺开始的新的钯/ scan双重催化方法，从而导致了经济上受阻的C3-萘化吲哚的原子经济合成，产率中等至良好，区域选择性高。该方法可以耐受正常的空气条件，并具有使用不带任何配体的钯//协同催化剂，涉及各种内部炔烃的简便双环化以及良好的官能团耐受性的特点。

更新日期：2020-08-23

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11