Adipogenesis has been extensively studied using in vitro models of cellular differentiation, enabling long-term regulation of fat cell metabolism in human adipose tissue (AT) material. Many studies promote the idea that manipulation of this process could potentially reduce the prevalence of obesity and its related diseases. It has now become essential to understand the molecular basis of fat cell development to tackle this pandemic disease, by identifying therapeutic targets and new biomarkers. This review explores murine cell models and their applications for study of the adipogenic differentiation process in vitro. We focus on the benefits and limitations of different cell line models to aid in interpreting data and selecting a good cell line model for successful understanding of adipose biology.

已经使用细胞分化的体外模型对脂肪生成进行了广泛的研究，从而能够长期调节人类脂肪组织 (AT) 材料中的脂肪细胞代谢。许多研究促进了这样一种观点，即操纵这一过程可能会降低肥胖及其相关疾病的患病率。现在，通过确定治疗靶点和新的生物标志物来了解脂肪细胞发育的分子基础以应对这种流行病已变得至关重要。本综述探讨了鼠细胞模型及其在体外成脂分化过程研究中的应用. 我们专注于不同细胞系模型的优点和局限性，以帮助解释数据和选择良好的细胞系模型以成功理解脂肪生物学。