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Flexible Chemical Sensors Using Signal Generation from Cyclodextrin-Analyte Interactions on Polymer Composites
BioChip Journal ( IF 5.5 ) Pub Date : 2020-08-19 , DOI: 10.1007/s13206-020-4303-3
Joonwon Bae , Dong-Sik Shin , Ji-Hwan Ha , Yunjung Hwang , Chang-Soo Lee , Hye Jun Kim , Ayeon Jang , Sung-Hoon Park

We present the design of a chemical sensor and study the generation of electrical signals produced by the formation of a cyclodextrin inclusion complex. Flexible poly(dimethylsiloxane)/graphene hybrid composites were used as sensor substrates and sensing media, beta-cyclodextrin (beta-CD) molecules were incorporated using simple bio-coupling reactions. The feasibility of sensing molecules through the formation of beta-CD/analyte inclusion complexes was investigated systematically using direct electrical measurement. The acquisition and transduction of electrical signals generated by inclusion complex formation is a central focus of this study and extensive complementary experiments were carried out to characterize this phenomenon. Because it is useful for development of a sort of sensor system, electrical measurements were performed to measure the sensitivity of this system (10 nM). However, more study is required to determine the selectivity. This article will be a useful reference for the design of versatile chemical sensors utilizing a non-toxic sensing medium on flexible composite substrates.



中文翻译:

柔性化学传感器,利用聚合物复合材料上的环糊精与分析物相互作用生成信号

我们提出了一种化学传感器的设计,并研究了由环糊精包合物形成所产生的电信号的产生。柔性聚(二甲基硅氧烷)/石墨烯杂化复合材料用作传感器基材和传感介质,使用简单的生物偶联反应将β-环糊精(β-CD)分子引入。使用直接电测量系统地研究了通过形成β-CD/分析物包合物的方式来检测分子的可行性。由夹杂物形成形成的电信号的获取和转导是这项研究的重点,并进行了广泛的补充实验以表征这种现象。因为它对于开发一种传感器系统很有用,进行电学测量以测量该系统的灵敏度(10 nM)。但是,需要更多的研究来确定选择性。本文将为在柔性复合材料基板上使用无毒传感介质的通用化学传感器的设计提供有用的参考。

更新日期:2020-08-23
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