We investigated the effects of long-term repeated treatments with a sustainable gonadotropin-releasing hormone (GnRH) antagonist, degarelix acetate, on testicular hormonal secretion, size, ultrasound images, histology and spermatogenesis in goats to assess its efficacy as a chemical castration method. Male Shiba goats (3–6 months of age) were treated subcutaneously with degarelix acetate every 4 weeks for 24 weeks. Plasma testosterone and insulin-like peptide 3 concentrations decreased (P < 0.05) within 2 days after the first treatment and remained low until 29 weeks (P < 0.05). Scrotal circumference and testicular pixel intensity were lower from 2–6 months and from 1–6 months, respectively, compared to the pretreatment values (P < 0.05). The testis and epididymis weights were lower at 24 weeks compared to those in untreated goats (P < 0.05). There were no sperm in the seminiferous tubules of testicular tissue sections or in homogenates of the epididymis at 24 weeks. These results suggest that repeated treatment with degarelix acetate is an effective chemical castration method for goats.

中文翻译：

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长期重复治疗可持续 GnRH 拮抗剂醋酸地加瑞克对山羊睾丸功能的抑制作用

我们研究了用可持续的促性腺激素释放激素 (GnRH) 拮抗剂醋酸地加瑞克长期重复治疗对山羊睾丸激素分泌、大小、超声图像、组织学和精子发生的影响，以评估其作为化学阉割方法的功效。雄性 Shiba 山羊（3-6 月龄）每 4 周接受一次醋酸地加瑞克皮下治疗，持续 24 周。血浆睾酮和胰岛素样肽 3 浓度在第一次治疗后 2 天内下降（P < 0.05），并保持低水平直至 29 周（P < 0.05）。与治疗前值相比，阴囊周长和睾丸像素强度分别从 2-6 个月和 1-6 个月降低（P < 0.05）。与未经治疗的山羊相比，24 周时睾丸和附睾的重量较低（P < 0.05）。24周时睾丸组织切片的曲细精管或附睾匀浆中没有精子。这些结果表明，用醋酸地加瑞克反复处理是一种有效的山羊化学阉割方法。