ABSTRACT

Objectives

Hospital antibiotic consumption is measured using defined-daily-doses (DDD) divided by bed days. However,other denominators as discharges could provide a more accurate interpretation of consumption. The main objective was to analyze trends of antibiotic consumption among hospitals in Catalonia during the period 2008–2016, using both DDD/100 bed days and DDD/100 discharges.

Methods

Retrospective, descriptive, and longitudinal study performed among acute care hospitals affiliated to VINCat Program. Antibiotic consumption was expressed using the Anatomical Therapeutic Chemical/DDD classification and trends with a mixed linear model. Trends after using both DDD/100 bed days and DDD/100 discharges were determined and compared.

Results

Overall antibiotic consumption from 2008 to 2016 increased by 10.24% (P < 0.001) DDD/100 bed days, but remained stable (−0.87%, P = 0.051) in DDD/100 discharges. Although DDD and discharges remained unchanged, a significant reduction in bed days (−9.63%) and length of stay (−8.19%) was observed. A worrisome increase in the consumption of carbapenems and anti-MRSA drugs was noticed.

Conclusion

Whereas a significant upward trend in antibiotic consumption in DDD/100 bed days was noticed, DDD/100 discharges remained stable. The description of both indicators seems therefore essential for a correct interpretation of data.

中文翻译：

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加泰罗尼亚急诊医院抗生素消费趋势（2008-2016）：不同调整对结果的影响

摘要

目标

医院抗生素消耗量是使用每日限定剂量 (DDD) 除以住院天数来衡量的。但是，排放等其他分母可以提供更准确的消费解释。主要目标是分析 2008 年至 2016 年期间加泰罗尼亚医院的抗生素消费趋势，使用 DDD/100 个床位日和 DDD/100 出院。

方法

在隶属于 VINCat 计划的急症护理医院中进行的回顾性、描述性和纵向研究。抗生素消耗使用解剖治疗化学/DDD 分类和趋势与混合线性模型表示。确定并比较使用 DDD/100 个床位天数和 DDD/100 个出院后的趋势。

结果

从 2008 年到 2016 年，抗生素总消耗量增加了 10.24% ( P < 0.001) DDD/100 床日，但在 DDD/100 排放量中保持稳定 (-0.87%, P = 0.051)。尽管 DDD 和出院量保持不变，但观察到卧床天数 (-9.63%) 和住院时间 (-8.19%) 显着减少。注意到碳青霉烯类药物和抗 MRSA 药物的消费量出现令人担忧的增长。

结论

尽管注意到 DDD/100 床日的抗生素消耗量有显着上升趋势，但 DDD/100 的排放量保持稳定。因此，这两个指标的描述对于正确解释数据似乎是必不可少的。