One new furoquinoline alkaloid, leptanoine D (1) and nine known alkaloids 2–10 were isolated from Pitaviaster haplophyllus. Leptanoine D (1) contains a typically unstable vinyl ether moiety and was structurally elucidated based on 2D NMR, (+)-HR-ESI-MS, and ECD data. The structures of the known furoquinoline alkaloids leptanoine A (11) and B (12) have also been revised. Compounds 1–10 were screened against three species of bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli), however they showed no activity at the highest dose tested (32 µg mL⁻¹). The compounds were also evaluated for anti-proliferative action against PC-3 and WPMY-1 cells, with 7–9 displaying weak activity at 100 μM.

一个新furoquinoline生物碱，leptanoine d（1）和9种已知生物碱2 - 10从分离Pitaviaster haplophyllus。瘦素D（1）包含一个通常不稳定的乙烯基醚部分，并根据2D NMR，（+）-HR-ESI-MS和ECD数据进行结构阐明。已知呋喃喹啉生物碱瘦素A（11）和B（12）的结构也已修改。化合物1 - 10进行了筛选针对三种细菌（金黄色葡萄球菌，铜绿假单胞菌，和大肠埃希氏菌），但在最高测试剂量（32 µg mL ^-1）下没有活性。这些化合物也评价针对PC-3和WPMY-1细胞，抗增殖作用与7 - 9在100μM显示弱的活性。