The synthesis of novel pyrrolo[1,2-c][1,3]benzodiazepine and pyrrolo[3,2-c]- [1]benzazepine ring systems from (2-aminophenyl)(1H-pyrrol-2-yl)methanone and 2-[(1H-pyrrol-2-yl)methyl]aniline is presented, utilizing triphosgene as carbonylation-cyclization reagent for the formation of the 7-membered heterocycle. A study of the reaction shows that small changes in the reaction conditions affect dramatically the course of the reaction. Acidity as well as aqueous workup play significant roles in the reaction outcome, directing product formation and revealing important aspects of triphosgene mediated cyclizations.

中文翻译：

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三光气-三乙胺的可调反应性：基于吡咯的三环化合物的合成研究

由（2-氨基苯基）（1 H-吡咯-2-基）合成新型吡咯并[1,2- c ] [1,3]苯并二氮杂和吡咯并[3,2- c ]-[1]苯并ze庚环体系提出了利用三光气作为羰基化环化试剂形成7元杂环的方法，研究了甲酮和2-[（（1 H-吡咯-2-基）甲基]苯胺。对反应的研究表明，反应条件的微小变化会极大地影响反应过程。酸度和水溶液后处理在反应结果中起重要作用，指导产物形成并揭示三光气介导的环化的重要方面。