The new subtipyrrolines A–C were discovered from the hadal bacterium Bacillus subtilis SY2101 isolated from a sample of sediment collected at the Mariana Trench. Their structures were elucidated based on the HRESIMS data, extensive NMR spectroscopic analyses, ECD and ¹³C NMR calculations, and single crystal X-ray diffraction experiment. Subtipyrrolines A–C possessed an unprecedented pyrrole-pyrrole-dihydropyridine tricyclic skeleton. Subtipyrrolines A and C showed weak antiproliferative activities against human glioma U251 and U87MG cells, respectively, and subtipyrrolines A–C had weak antimicrobial activities in inhibiting the growth of Escherichia coli and Candida albicans. The plausible biosynthetic pathway of subtipyrrolines A–C was also proposed.

从枯草芽孢杆菌SY2101细菌中发现了新的亚吡咯啉AC，该细菌是从马里亚纳海沟收集的沉积物样品中分离出来的。根据HRESIMS数据，广泛的NMR光谱分析，ECD和¹³ C NMR计算以及单晶X射线衍射实验，阐明了它们的结构。吡咯亚烷基AC具有前所未有的吡咯-吡咯-二氢吡啶三环骨架。副甲状腺素A和C分别对人神经胶质瘤U251和U87MG细胞具有较弱的抗增殖活性，副甲状腺素A-C在抑制大肠杆菌和白色念珠菌生长方面具有较弱的抗菌活性。。还提出了亚吡咯啉AC的合理的生物合成途径。