Polymorphatin A was reported as a constituent of Marchantia polymorpha in 2007 following much speculation as to its likely existence as a natural product. Interest was rekindled when a claimed total synthesis revealed inconsistencies in spectral data between the synthetic sample and those reported for the natural product. Herein we describe a total synthesis of polymorphatin A, supported by an X-ray crystal structure of its trimethyl ether, that adds further intrigue as our synthetic sample displays physical and spectral characteristics that differ from data provided in the aforementioned reports.

中文翻译：

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全合成多晶型蛋白A，一种具有船型芳烃的大环双联苄基

据报道，多形蛋白A是多形花March的成分，此前人们猜测它可能作为天然产物存在。当要求保护的总合成显示合成样品与天然产物报告的光谱数据不一致时，人们重新燃起了兴趣。在这里，我们描述了由其三甲醚的X射线晶体结构支持的多形变体A的全合成，由于我们的合成样品显示的物理和光谱特性与上述报告中提供的数据不同，因此进一步增加了人们的兴趣。