Hereby, the effectiveness of ibuprofen release from chitosan/polyvinyl alcohol blend films prepared by solvent casting method was studied as a function of blend composition and cross-linking density. Genipin was used as the cross-linker. Miscibility of blend components was verified by FTIR and SEM analyses. Based on the results of ninhydrin assay, optimal genipin concentration was determined as 0.25 mM. Genipin induced inter and intramolecular hydrogen bonding aided in the enhancement of tensile strength and mechanical stability as shown with swelling tests. Concordantly, burst release was hindered and more efficient release profile was obtained for crosslinked blend. The kinetics of ibuprofen release was best described by Korsmeyer Peppas model implying that diffusion and polymer relaxation were the underlying mechanisms for either non-crosslinked or genipin cross-linked blends. Over 96% of cell viability was recorded in WST-1 assay. All these results suggested that ibuprofen encapsulated chitosan polyvinyl alcohol blends crosslinked by genipin could be used as pain suppressing wound dressing material.

因此，研究了由溶剂流延法制备的壳聚糖/聚乙烯醇共混物薄膜中布洛芬释放的效果，其与共混物组成和交联密度的关系。Genipin被用作交联剂。共混物组分的混溶性通过FTIR和SEM分析得到验证。根据茚三酮测定的结果，确定最佳的京尼平浓度为0.25 mM。Genipin诱导的分子间和分子内氢键有助于增强抗张强度和机械稳定性，如溶胀试验所示。相应地，阻碍了突发释放，并且对于交联的共混物获得了更有效的释放特性。布洛芬释放的动力学由Korsmeyer Peppas模型最好地描述，这表明扩散和聚合物松弛是非交联或Genipin交联混合物的潜在机制。在WST-1分析中记录了超过96％的细胞活力。所有这些结果表明，布洛芬包囊化的壳聚糖聚乙烯醇混合物经Genipin交联可以用作镇痛创面护理材料。