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Ent-clerodane and ent-trachylobane diterpenoids from Croton dictyophlebodes
Phytochemistry ( IF 3.2 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.phytochem.2020.112487 Joan J E Munissi 1 , Sani M Isyaka 2 , Eduard Mas-Claret 2 , Molly Brabner 2 , Moses K Langat 3 , Stephen S Nyandoro 1 , Dulcie A Mulholland 4
Phytochemistry ( IF 3.2 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.phytochem.2020.112487 Joan J E Munissi 1 , Sani M Isyaka 2 , Eduard Mas-Claret 2 , Molly Brabner 2 , Moses K Langat 3 , Stephen S Nyandoro 1 , Dulcie A Mulholland 4
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The stem bark and root bark extracts of Croton dictyophlebodes (Euphorbiaceae) yielded seven undescribed ent-clerodanes: 15,16-epoxy-17,12(S)-olide-ent-cleroda-1,3,13(16),14-tetraen-18-oic acid methyl ester (crotodictyo A), 3β,4β:15,16-diepoxy-ent-cleroda-13(16),14-dien-20-al (crotodictyo B), 3β,4β:15,16-diepoxy-ent-cleroda-13(16),14-dien-19,20-dioic acid (crotodictyo C), 3β,4β:15,16-diepoxy-ent-cleroda-13(16),14-dien-20,19-olide (crotodictyo D), 3β,4β:15,16-diepoxy-20,12(R)-olide ent-cleroda-13(16),14-dien-19-oic acid methyl ester (crotodictyo E), 15,16-epoxy-ent-cleroda-3,13(16),14-trien-12-oxo-18-oic acid (crotodictyo F) and 15,16-epoxy-ent-cleroda-1,3,13(16),14-tetraen-12-oxo-18-oic acid (crotodictyo G), in addition to 15,16-epoxy- ent-cleroda-3,13(16),14-trien-12-oxo-18-oic acid methyl ester (crotodictyo H), reported previously as a synthetic derivative, and acetyl aleuritolic acid. The root extract yielded two ent-trachylobanes, ent-trachylobane-18,19-diol, the undescribed ent-trachylobane-2α,19-diol, along with ent-kaur-16-en-19-oic acid and 2-methoxybenzyl benzoate. Compounds were evaluated against the NCI 60 panel of human tumour cell lines at a single dose of 10-5 M, but showed no significant activity.
中文翻译：
来自巴豆 dictyophlebodes 的 Ent-clerodane 和 ent-trachylobane 二萜
先前报道为合成衍生物，和乙酰基糊精酸。根提取物产生两种 ent-trachylobane，ent-trachylobane-18,19-diol，未描述的 ent-trachylobane-2α,19-diol，以及 ent-kaur-16-en-19-oic 酸和 2-甲氧基苯甲酸苄酯. 以 10-5 M 的单剂量针对 NCI 60 组人肿瘤细胞系评估化合物，但没有显示出显着的活性。
更新日期：2020-11-01
中文翻译：
来自巴豆 dictyophlebodes 的 Ent-clerodane 和 ent-trachylobane 二萜
先前报道为合成衍生物，和乙酰基糊精酸。根提取物产生两种 ent-trachylobane，ent-trachylobane-18,19-diol，未描述的 ent-trachylobane-2α,19-diol，以及 ent-kaur-16-en-19-oic 酸和 2-甲氧基苯甲酸苄酯. 以 10-5 M 的单剂量针对 NCI 60 组人肿瘤细胞系评估化合物，但没有显示出显着的活性。
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