In rodents, neurotensin contributes to high fat diet induced obesity by facilitation of intestinal fat absorption. The effect of oral lipid load on plasma proneurotensin and relationship with plasma triglycerides in humans is unknown. To investigate the acute effects of an oral lipid load on proneurotensin and plasma triglycerides and their interrelationships in healthy individuals. Twenty-two healthy subjects were given 150 mL of full milk cream (54 g fat) and 59 mL of pure olive oil (54 g fat) in the fasted state at two different occasions separated by at least 1 week in random order. Venous blood was drawn at fasted before 0 h (h) and at 1 h, 2 h and 4 h after ingestion. Post-ingested values of proneurotensin and plasma triglycerides were compared with fasting levels and post ingestion Area Under the Curve (AUC) of proneurotensin was correlated with that of plasma triglycerides. An immediate rise of plasma proneurotensin and plasma triglycerides were observed after ingestion of cream with maximum increase at 2 h for proneurotensin [mean (95% confidence interval)] of 22 (12–31) pmol/L (P < 0.001) and at 3 h for triglycerides of 0.60 (0.43–0.78) mmol/L (P < 0.001). Similarly, plasma proneurotensin and plasma triglycerides increased after ingestion of olive oil with maximum increase of proneurotensin at 3 h of 62 (46–78) pmol/L (P < 0.001) and plasma triglycerides at 3 h of 0.32 (0.18–0.45) mmol/L (P < 0.001). The post lipid load AUC for proneurotensin correlated significantly with the AUC for plasma triglycerides both after cream (r = 0.49, P = 0.021) and olive oil (r = 0.55, P = 0.008), respectively. Proneurotensin increases after an oral lipid load of both cream and olive oil and the rise of post-ingestion plasma triglycerides is significantly related to the rise of post-ingestion proneurotensin.

中文翻译：

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标准化口服摄入饱和和不饱和脂肪后，神经降压素的升高幅度与血液中甘油三酯的出现量有关。

在啮齿动物中，神经降压素通过促进肠内脂肪吸收而促进高脂饮食诱导的肥胖。口服脂质负荷对人血浆神经降压素的影响以及与血浆甘油三酸酯的关系尚不清楚。研究口服脂质负荷对神经降压素和血浆甘油三酸酯及其在健康个体中的相互关系的急性影响。22名健康受试者在两次不同的情况下，分别以至少1周的随机间隔分别禁食了150毫升全脂乳霜（54克脂肪）和59毫升纯橄榄油（54克脂肪），间隔至少1周。禁食前0 h（h）和摄取后1 h，2 h和4 h抽取静脉血。将神经营养素和血浆甘油三酸酯的摄取后值与禁食水平进行比较，神经营养素的曲线下摄取面积（AUC）与血浆甘油三酸酯的摄取后相关。摄入乳脂后，血浆神经降压素和血浆甘油三酸酯立即升高，在2 h前神经降压素[平均值（95％置信区间）]最大增加为22（12-31）pmol / L（P <0.001），在3甘油三酸酯的h为0.60（0.43-0.78）mmol / L（P <0.001）。同样，摄入橄榄油后血浆中神经降压素和血浆甘油三酸酯增加，其中3个小时前神经降压素的最大增加量为62（46-78）pmol / L（P <0.001），3个小时时血浆甘油三酸酯的增加量为0.32（0.18-0.45）mmol /升（P <0.001）。降脂后（r = 0.49，P = 0.021）和橄榄油（r = 0.55，P = 0.008）后，神经降压素的脂质负荷后AUC与血浆甘油三酸酯的AUC显着相关。口服奶油和橄榄油中的脂质负荷后，神经降压素升高，而摄入后血浆甘油三酸酯的升高与摄入后降压前神经紧张素的升高显着相关。