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LRP6 lets Merlin go in times of nutrient scarcity.
EMBO Reports ( IF 6.5 ) Pub Date : 2020-08-20 , DOI: 10.15252/embr.202051358
Kenneth Kin Lam Wong 1, 2 , Esther M Verheyen 1, 2
Affiliation  

Cells take advantage of cross‐talk in signaling pathways to integrate diverse signals and produce coordinated responses. In this issue of EMBO Reports, Jeong et al discover that the Wnt co‐receptor, low‐density lipoprotein (LDL) receptor‐related protein LRP6, negatively regulates Hippo signaling by serving as a binding sink to sequester and inhibit Merlin, an activator of Hippo signaling (Jeong et al, 2020). This regulation is nutrient‐responsive, likely using LRP6 O‐GlcNAcylation as a molecular switch.

中文翻译:

LRP6 让 Merlin 在营养缺乏的时候去。

细胞利用信号通路中的串扰来整合不同的信号并产生协调的反应。在本期EMBO 报告中, Jeong等人发现 Wnt 共同受体、低密度脂蛋白 (LDL) 受体相关蛋白 LRP6 通过作为结合汇来隔离和抑制 Merlin(一种激活剂)来负调节 Hippo 信号传导。 Hippo 信号(Jeong等人,2020 年)。这种调节是营养响应的,可能使用 LRP6 O- GlcNAcylation 作为分子开关。
更新日期:2020-09-03
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