Abstract: There is no specific and effective medication for coronavirus disease 2019 (COVID-19), and avaccine is not available in recent months. Here, we hypothesize that a single large dose of vitamin D (Vit D) could be an option for trial in COVID-19. Vit D deficiency or insufficiency is very common in the general population as well as in patients with COVID-19. It has been shown that low Vit D level is associated with viral infection, and Vit D supplementation is beneficial for people infected with viruses, such as HIV and hepatitis C virus. Although COVID-19 is a respiratory disease, the morbidity and mortality of this disease are driven by coagulopathy. Clinical studies have shown that Vit D can exert anticoagulant effects. Vit D, a lipid-soluble vitamin, can be administered as a draught. Vit D supplementation is safe and has rare toxic events. In addition, the cost of Vit D is fairly low. Based on these observations, we speculate that a single dose of 300,000 IU Vit D may have a role in the prevention and treatment of COVID-19.

Keywords: vitamin D, large dose, coronavirus disease 2019


中文翻译：

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大剂量的维生素D可以用作2019年冠状病毒疾病的预防和治疗手段。

摘要：目前尚无针对2019年冠状病毒疾病（COVID-19）的特效药物，近几个月来没有疫苗可用。在这里，我们假设单剂量大剂量的维生素D（Vit D）可能是在COVID-19中进行试验的一种选择。Vit D缺乏或机能不全在普通人群以及COVID-19患者中非常普遍。已经表明，低的Vit D水平与病毒感染有关，补充Vit D对感染了病毒（如HIV和丙型肝炎病毒）的人有益。尽管COVID-19是一种呼吸系统疾病，但该疾病的发病率和死亡率是由凝血病驱动的。临床研究表明，维生素D可以发挥抗凝作用。Vit D是一种脂溶性维生素，可以吃得透风。补充维生素D是安全的，并具有罕见的毒性事件。另外，Vit D的成本相当低。基于这些观察，我们推测单剂300,000 IU Vit D可能在预防和治疗COVID-19中起作用。

关键字：维生素D，大剂量，冠状病毒病2019