The incidence rate of (EC) has increased significantly in the past 2 decades. The current chemotherapy for this disease can cause intolerable side effects. Recently, both cordycepin and gold nanostars have demonstrated the ability to inhibit the growth and differentiation of cancers. This study aimed to investigate the antiEC effects of cordycepin, gold nanostars (Au NS), and the combination of the two. The gold nanostars were made by seed-mediated reduction, and their morphology was confirmed by laser particle size analysis, spectrophotometry, and electron microscopy. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cytotoxicity assays, clonogenic assays, and flow cytometry were employed to evaluate the inhibition rate, survival fraction, and apoptosis in HEC-1A cells under different concentrations of cordycepin, Au NS, and their combination. This study revealed that both cordycepin and Au NS with 808 nm light exposure could inhibit cell proliferation, cause cell apoptosis, and inhibit the clone ability of EC cells. This study supports further investigations into Au NS-cordycepin in the development of new treatments for EC.

在过去的20年中，（EC）的发病率显着增加。当前对该疾病的化学疗法可引起无法忍受的副作用。最近，虫草素和金纳米星均已显示出抑制癌症生长和分化的能力。这项研究旨在研究虫草素，金纳米星（Au NS）以及两者的组合的抗EC作用。通过种子介导的还原制备金纳米星，并通过激光粒度分析，分光光度法和电子显微镜确认其形态。用3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑溴化物细胞毒性测定，克隆形成测定和流式细胞术评估不同浓度下HEC-1A细胞的抑制率，存活率和凋亡虫草素，金NS 及其组合。这项研究表明，虫草素和Au NS在808 nm的光照下均可抑制细胞增殖，引起细胞凋亡，并抑制EC细胞的克隆能力。这项研究支持对Au NS-cordycepin的进一步研究，以开发EC的新疗法。