β-Pinene can be used as a cheap source to synthesize a large number of high value-added derivatives. In this study, a series of β-pinene derivatives was prepared, and the antifungal activities of the compounds were assessed against phytopathogenic fungi. Eight N-alkyl hydronopyl diethyl ammonium halide salts were synthesized by the reaction of hydronopyl diethyl ammonium halide with 8 halogenated alkanes. The structures of the synthesized products were characterized by Fourier-transform infrared spectroscopy and nuclear magnetic resonance spectroscopy and mass spectrometry. The antifungal activities of these derivatives were tested against 11 plant pathogens, and the preliminary structure-activity relationship is discussed. Some derivatives exhibited moderate to significant antifungal activity due to the fusion of the hydronopyl, a long-chain alkyl, bromine, and iodine anionic groups. In contrast to the structure-activity relationship of compounds 2a, 2b, and 2c, iodine ions in 2f, 2g, and 2f had a significant effect on enhancing the antifungal activity against Colletotrichum gloeosporioides, Sclerotinia sclerotiorum, Phytophthora capsici, Phomopsis, Sphaeropsis sapinea, Glomerella cingulata, and Fusicoccum aesculi. A higher molecular weight could increase the antifungal activity against Fusarium proliferatum, Alternaria kikuchiana, Sclerotinia sclerotiorum, P. capsici, Phomopsis, and S. sapinea. Compounds 2d and 2e exhibited broad-spectrum antifungal activity against the tested strains. These derivatives are expected to be used as precursor molecules for novel pesticide development in further research.

β-P烯可用作合成大量高附加值衍生物的廉价来源。在这项研究中，制备了一系列的β-pine烯衍生物，并评估了该化合物对植物致病真菌的抗真菌活性。八N羟烷基二乙基卤化铵与8个卤代烷烃的反应合成了烷基-烷基羟乙基二卤化铵盐。用傅立叶变换红外光谱，核磁共振光谱和质谱对合成产物的结构进行了表征。测试了这些衍生物对11种植物病原体的抗真菌活性，并讨论了其初步的构效关系。由于羟丙基，长链烷基，溴和碘阴离子基团的融合，一些衍生物表现出中等至重要的抗真菌活性。与化合物2a，2b和2c的结构-活性关系相反，碘离子在2f中，2克和2F对增强抗抗真菌活性一个显著影响炭疽病，S clerotinia菌核病，辣椒疫霉，拟茎点霉，枯梢，炭疽病和Fusicoccum aesculi。更高的分子量可以增加针对抗真菌活性镰刀菌，梨黑斑病菌，菌核病，辣椒疫霉，拟茎点霉，和S.梢。化合物2d和2e显示出对测试菌株的广谱抗真菌活性。这些衍生物有望在进一步研究中用作新型农药开发的前体分子。