The pathogenesis of Alzheimer’s disease (AD) is complex as various mechanisms interact with each other and, therefore, intervention from a single target is often ineffective. Many studies have shown that herbal medicines, such as curcumin, fisetin, icariin, and ginsenosides, have significant intervention effects on AD with different treatment mechanisms. Therefore, we have designed this study to know whether the combination of these herbal medicines can have an intervention effect on AD through multiple targets. Amyloid precursor protein/presenilin 1(APP/PS1) double transgenic AD mice were used to study the protective effects of a combination of curcumin, piperine, icariin, and ginsenosides, as well as a combination of fisetin, piperine, icariin, and ginsenosides, which were separately mixed into the feed. These herbal medicinal compounds (HMCs) lowered the serum lipid levels, reduced the Aβ oligomers, decreased the pS404-tau protein, as well as neurofibrillary tangles, and restored the reduction of synaptic protein levels and neuronal death of AD mice without causing toxicity to liver and kidneys. In this study, we found that HMCs have significant intervention against AD through multiple targets, providing a novel therapeutic idea for the prevention of AD.

阿尔茨海默氏病（AD）的发病机制很复杂，因为各种机制相互影响，因此，单一目标的干预通常无效。许多研究表明，姜黄素，非瑟汀，柠檬酸和人参皂苷等草药以不同的治疗机制对AD具有显着的干预作用。因此，我们设计了这项研究，以了解这些草药的组合是否可以通过多个目标对AD产生干预作用。使用淀粉样蛋白前体蛋白/早老素1（APP / PS1）双转基因AD小鼠研究姜黄素，胡椒碱，苦瓜素和人参皂甙组合以及非瑟汀，胡椒碱，苦参素和人参皂甙组合的保护作用，将它们分别混入饲料中。这些草药化合物（HMCs）降低了血清脂质水平，降低了Aβ低聚物，降低了pS404-tau蛋白以及神经原纤维缠结，并恢复了AD小鼠突触蛋白水平的降低和神经元死亡，而不会引起肝毒性和肾脏。在这项研究中，我们发现HMC可通过多个靶点对AD进行显着干预，从而为预防AD提供了新的治疗思路。