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Depression and quality of life after cerebral venous sinus thrombosis
Annals of Indian Academy of Neurology ( IF 1.9 ) Pub Date : 2020-07-01 , DOI: 10.4103/aian.aian_191_19 Aralikatte O Saroja 1 , Ninad N Thorat 1 , Karkal R Naik 1
Introduction: Cerebral venous sinus thrombosis (CVST) is an important cause of stroke in young and has a favorable outcome. Long-term sequelae of CVST include motor disability, cognitive impairment, depression, anxiety, fatigue, impaired employment and poor quality of life. Objective: To evaluate depression and quality of life after CVST. Methods: Patients who completed at least 1 year after discharge were recruited for this cross-sectional observational study from our CVST cohort. Quality of life was assessed using Stroke-Adapted Sickness Impact Profile (SA-SIP 30) and depression using Hamilton Depression scale (HAM-D). Results: A total of 100 patients (60 men and 40 women) were included in the study. Their age ranged from 14 to 60 years (34.97 ± 10.06). The interval from discharge to assessment of quality of life was 2.2 ± 1.6 years. In all, 98% of patients had good modified Rankin score at follow-up. SA-SIP 30 did not reveal any functional disability for physical functioning. Seven had impairment for psychosocial domain despite having good modified Rankin scores. Thirty patients had depression. Patients with higher mRS at discharge had increased presence of depression. Quality-of-life scores did not correlate with presence of seizure, headache, infarction and sinuses involved. Conclusion: This is the first Indian study demonstrating depression in patients with CVST and use of SA-SIP to assess quality of life in them. Occurrence of depression in CVST is as high as in arterial strokes.
中文翻译：
脑静脉窦血栓形成后的抑郁与生活质量
简介：脑静脉窦血栓形成（CVST）是年轻人脑卒中的重要原因，预后良好。CVST 的长期后遗症包括运动障碍、认知障碍、抑郁、焦虑、疲劳、就业受损和生活质量差。目的：评估 CVST 后的抑郁和生活质量。方法：从我们的 CVST 队列中招募出院后至少 1 年完成的患者进行这项横断面观察性研究。使用中风适应疾病影响档案 (SA-SIP 30) 评估生活质量，使用汉密尔顿抑郁量表 (HAM-D) 评估抑郁症。结果：共有 100 名患者（60 名男性和 40 名女性）被纳入研究。他们的年龄从 14 岁到 60 岁不等 (34.97 ± 10.06)。从出院到评估生活质量的时间间隔为 2.2 ± 1.6 年。总之，98% 的患者在随访时改良 Rankin 评分良好。SA-SIP 30 没有发现任何身体机能的功能障碍。尽管有良好的改良 Rankin 分数，但 7 人的心理社会领域存在障碍。三十名患者患有抑郁症。出院时 mRS 较高的患者出现抑郁的情况增加。生活质量评分与癫痫发作、头痛、梗塞和涉及的鼻窦无关。结论：这是第一个印度研究表明 CVST 患者患有抑郁症并使用 SA-SIP 来评估他们的生活质量。CVST 中抑郁症的发生率与动脉卒中一样高。
更新日期：2020-08-21
Annals of Indian Academy of Neurology ( IF 1.9 ) Pub Date : 2020-07-01 , DOI: 10.4103/aian.aian_191_19 Aralikatte O Saroja 1 , Ninad N Thorat 1 , Karkal R Naik 1
Affiliation
Introduction: Cerebral venous sinus thrombosis (CVST) is an important cause of stroke in young and has a favorable outcome. Long-term sequelae of CVST include motor disability, cognitive impairment, depression, anxiety, fatigue, impaired employment and poor quality of life. Objective: To evaluate depression and quality of life after CVST. Methods: Patients who completed at least 1 year after discharge were recruited for this cross-sectional observational study from our CVST cohort. Quality of life was assessed using Stroke-Adapted Sickness Impact Profile (SA-SIP 30) and depression using Hamilton Depression scale (HAM-D). Results: A total of 100 patients (60 men and 40 women) were included in the study. Their age ranged from 14 to 60 years (34.97 ± 10.06). The interval from discharge to assessment of quality of life was 2.2 ± 1.6 years. In all, 98% of patients had good modified Rankin score at follow-up. SA-SIP 30 did not reveal any functional disability for physical functioning. Seven had impairment for psychosocial domain despite having good modified Rankin scores. Thirty patients had depression. Patients with higher mRS at discharge had increased presence of depression. Quality-of-life scores did not correlate with presence of seizure, headache, infarction and sinuses involved. Conclusion: This is the first Indian study demonstrating depression in patients with CVST and use of SA-SIP to assess quality of life in them. Occurrence of depression in CVST is as high as in arterial strokes.
中文翻译：
脑静脉窦血栓形成后的抑郁与生活质量
简介：脑静脉窦血栓形成（CVST）是年轻人脑卒中的重要原因，预后良好。CVST 的长期后遗症包括运动障碍、认知障碍、抑郁、焦虑、疲劳、就业受损和生活质量差。目的：评估 CVST 后的抑郁和生活质量。方法：从我们的 CVST 队列中招募出院后至少 1 年完成的患者进行这项横断面观察性研究。使用中风适应疾病影响档案 (SA-SIP 30) 评估生活质量，使用汉密尔顿抑郁量表 (HAM-D) 评估抑郁症。结果：共有 100 名患者（60 名男性和 40 名女性）被纳入研究。他们的年龄从 14 岁到 60 岁不等 (34.97 ± 10.06)。从出院到评估生活质量的时间间隔为 2.2 ± 1.6 年。总之，98% 的患者在随访时改良 Rankin 评分良好。SA-SIP 30 没有发现任何身体机能的功能障碍。尽管有良好的改良 Rankin 分数，但 7 人的心理社会领域存在障碍。三十名患者患有抑郁症。出院时 mRS 较高的患者出现抑郁的情况增加。生活质量评分与癫痫发作、头痛、梗塞和涉及的鼻窦无关。结论：这是第一个印度研究表明 CVST 患者患有抑郁症并使用 SA-SIP 来评估他们的生活质量。CVST 中抑郁症的发生率与动脉卒中一样高。
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