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The impact of the Coronavirus Disease-2019 pandemic on the psychological status and quality of life of myasthenia gravis patients
Annals of Indian Academy of Neurology ( IF 1.7 ) Pub Date : 2020-07-01 , DOI: 10.4103/aian.aian_551_20 Aleksandar Stojanov 1 , Jelena Stojanov 2 , Vuk Milosevic 1 , Marina Malobabic 1 , Goran Stanojevic 3 , Milos Stevic 3 , Gordana Djordjevic 1, 3
Objectives: The coronavirus disease 2019 (COVID-19) is the largest pandemic of our times. We wanted to investigate the impact of COVID-19 pandemic on the psychological status, quality of life (QoL) and quality of sleep (QoS) of myasthenia gravis (MG) patients. Methods: Data on the epidemiological and clinical characteristics of MG were collected. We used a self-designed questionnaire (consisting of 12 questions), a revised 15-item Myasthenia Gravis Quality of Life Questionnaire (MGQOL15r), a 36-item health survey of the Medical Outcomes Study Short Form (SF36), Pittsburgh sleep quality index (PSQI), Hamilton scales for the assessment of anxiety (HAM-A), and depression (HAMD) were used. We reassessed patients who were tested three years ago using the same questionnaires. Results: The study included 64 MG patients. We noticed a statistically significant difference between the results obtained three years ago and the results from April 2020 in PSQI scores (P < 0.01). MGQOL15r, SF36, and PSQI scores correlate with severe clinical manifestation, high scores on HAM-A and HAM-D (P < 0.01). Higher scores on HAM-D and fear that MG symptoms will be worse if the patient gets an upper respiratory infection were independent predictors of the lower SF36 scores. Regarding MGQOL15r-independent predictors of the higher score were higher scores on HAM-D. Conclusions: There is a significant impact of the COVID-19 epidemic on the psychological status and especially on the quality of sleep of MG patients. Healthcare organizations need to provide professional therapeutic advice and psychosocial support for this population of patients during the pandemic.
中文翻译：
2019冠状病毒病大流行对重症肌无力患者心理状态和生活质量的影响
目标： 2019 年冠状病毒病 (COVID-19) 是我们这个时代最大的流行病。我们想调查 COVID-19 大流行对重症肌无力 (MG) 患者的心理状态、生活质量 (QoL) 和睡眠质量 (QoS) 的影响。方法：收集有关 MG 的流行病学和临床特征的数据。我们使用了自行设计的问卷（由 12 个问题组成）、修订后的 15 项重症肌无力生活质量问卷 (MGQOL15r)、36 项医疗结果研究简表健康调查 (SF36)、匹兹堡睡眠质量指数(PSQI)、用于评估焦虑的汉密尔顿量表 (HAM-A) 和抑郁症 (HAMD)。我们使用相同的问卷重新评估了三年前接受测试的患者。结果：该研究包括 64 名 MG 患者。我们注意到三年前获得的结果与 2020 年 4 月的结果在 PSQI 得分方面存在统计学显着差异（P < 0.01）。MGQOL15r、SF36、PSQI评分与临床表现严重、HAM-A和HAM-D高分相关（P < 0.01）。HAM-D 得分较高以及担心患者上呼吸道感染时 MG 症状会恶化是 SF36 得分较低的独立预测因素。关于较高分数的 MGQOL15r 独立预测因子是 HAM-D 的较高分数。结论：COVID-19 流行对 MG 患者的心理状态，尤其是对睡眠质量有显着影响。医疗机构需要在大流行期间为这群患者提供专业的治疗建议和社会心理支持。
更新日期：2020-08-21
Annals of Indian Academy of Neurology ( IF 1.7 ) Pub Date : 2020-07-01 , DOI: 10.4103/aian.aian_551_20 Aleksandar Stojanov 1 , Jelena Stojanov 2 , Vuk Milosevic 1 , Marina Malobabic 1 , Goran Stanojevic 3 , Milos Stevic 3 , Gordana Djordjevic 1, 3
Affiliation
Objectives: The coronavirus disease 2019 (COVID-19) is the largest pandemic of our times. We wanted to investigate the impact of COVID-19 pandemic on the psychological status, quality of life (QoL) and quality of sleep (QoS) of myasthenia gravis (MG) patients. Methods: Data on the epidemiological and clinical characteristics of MG were collected. We used a self-designed questionnaire (consisting of 12 questions), a revised 15-item Myasthenia Gravis Quality of Life Questionnaire (MGQOL15r), a 36-item health survey of the Medical Outcomes Study Short Form (SF36), Pittsburgh sleep quality index (PSQI), Hamilton scales for the assessment of anxiety (HAM-A), and depression (HAMD) were used. We reassessed patients who were tested three years ago using the same questionnaires. Results: The study included 64 MG patients. We noticed a statistically significant difference between the results obtained three years ago and the results from April 2020 in PSQI scores (P < 0.01). MGQOL15r, SF36, and PSQI scores correlate with severe clinical manifestation, high scores on HAM-A and HAM-D (P < 0.01). Higher scores on HAM-D and fear that MG symptoms will be worse if the patient gets an upper respiratory infection were independent predictors of the lower SF36 scores. Regarding MGQOL15r-independent predictors of the higher score were higher scores on HAM-D. Conclusions: There is a significant impact of the COVID-19 epidemic on the psychological status and especially on the quality of sleep of MG patients. Healthcare organizations need to provide professional therapeutic advice and psychosocial support for this population of patients during the pandemic.
中文翻译：
2019冠状病毒病大流行对重症肌无力患者心理状态和生活质量的影响
目标： 2019 年冠状病毒病 (COVID-19) 是我们这个时代最大的流行病。我们想调查 COVID-19 大流行对重症肌无力 (MG) 患者的心理状态、生活质量 (QoL) 和睡眠质量 (QoS) 的影响。方法：收集有关 MG 的流行病学和临床特征的数据。我们使用了自行设计的问卷（由 12 个问题组成）、修订后的 15 项重症肌无力生活质量问卷 (MGQOL15r)、36 项医疗结果研究简表健康调查 (SF36)、匹兹堡睡眠质量指数(PSQI)、用于评估焦虑的汉密尔顿量表 (HAM-A) 和抑郁症 (HAMD)。我们使用相同的问卷重新评估了三年前接受测试的患者。结果：该研究包括 64 名 MG 患者。我们注意到三年前获得的结果与 2020 年 4 月的结果在 PSQI 得分方面存在统计学显着差异（P < 0.01）。MGQOL15r、SF36、PSQI评分与临床表现严重、HAM-A和HAM-D高分相关（P < 0.01）。HAM-D 得分较高以及担心患者上呼吸道感染时 MG 症状会恶化是 SF36 得分较低的独立预测因素。关于较高分数的 MGQOL15r 独立预测因子是 HAM-D 的较高分数。结论：COVID-19 流行对 MG 患者的心理状态，尤其是对睡眠质量有显着影响。医疗机构需要在大流行期间为这群患者提供专业的治疗建议和社会心理支持。
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