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Cerebral venous thrombosis, seasonal trends, and climatic influence: A region-specificstudy
Annals of Indian Academy of Neurology ( IF 1.7 ) Pub Date : 2020-07-01 , DOI: 10.4103/aian.aian_409_19 Sanjith Aaron 1 , Jeyaseelan Lakshmanan 2 , Thambu D Sudarsanam 3 , Kenneth Benjamin 4 , Jothilakshmi Durairaj 2 , Vivek Mathew 1 , Ajith Sivadasan 1 , A T Prabhakar 4 , Shyam Kumar N Keshava 4 , Pavitra R Mannam 4 , Prabhu Kirubakaran 1 , Jayaprakash Muliyil 5 , Mathew Alexander 1
Background and Purpose: Studies looking at seasonal variation on cerebral venous thrombosis (CVT) are few with conflicting conclusions. In this region-specific study, we looked for climatic influence and seasonal trends on the incidence of CVT. Methods: Imaging proven adult CVT cases treated over a period of 18 years from a specific geographical location with similar seasons and climatic conditions were studied. Metrological parameters prepared using 30 years of data was used. Quantum geographical information system (QGIS software) and SPSS v 22 were used for patient plotting and analysis. Results: Total of 970 cases were studied. The incidence was significantly higher in summer 411 (42.3%) compared with autumn 317 (32.7%) and winter 242 (25.05); P = 0.038. This trend was consistent across all the 18 years in time series analysis. Mean age was 33.5 years (range 18–88 years). A significant majority 673 (69.4%) were below 40 years of age; P = 0.012. Females constituted 394 (40.6%) of cases. Postpartum CVT cases constituted 237 (30%). Interaction analysis showed younger age (<40 years) were more vulnerable for CVT in summer; P = 0.009. There was no seasonal influence on postpartum CVT. Apart for a weak positive correlation between rain fall (r = 0.18, P < 0.01); humidity and cloud cover was not influencing the incidence. Conclusions: Higher ambient temperatures were consistently associated with higher incidence of CVT. This is the largest region-specific study on CVT in the world. These results may be applicable to other regions with similar climatic conditions.
中文翻译：
脑静脉血栓形成、季节性趋势和气候影响：特定地区的研究
背景和目的：关于脑静脉血栓形成 (CVT) 季节性变化的研究很少得出相互矛盾的结论。在这项针对特定地区的研究中，我们寻找气候对 CVT 发病率的影响和季节性趋势。方法：研究了从具有相似季节和气候条件的特定地理位置接受治疗超过 18 年的影像学证实成人 CVT 病例。使用了使用 30 年数据准备的计量参数。量子地理信息系统（QGIS 软件）和 SPSS v 22 用于患者绘图和分析。结果：共研究了970例。夏季411（42.3%）的发病率明显高于秋季317（32.7%）和冬季242（25.05）；磷= 0.038。这一趋势在所有 18 年的时间序列分析中都是一致的。平均年龄为 33.5 岁（范围 18-88 岁）。大多数 673 (69.4%) 人年龄在 40 岁以下；P = 0.012。女性占 394 例（40.6%）。产后 CVT 病例占 237 例 (30%)。交互作用分析显示，年龄较小（<40 岁）在夏季更容易发生 CVT；P = 0.009。对产后 CVT 没有季节性影响。除了降雨量之间呈弱正相关（r = 0.18，P < 0.01）；湿度和云量对发病率没有影响。结论：较高的环境温度始终与较高的 CVT 发生率相关。这是世界上最大的针对 CVT 的地区性研究。这些结果可能适用于其他气候条件相似的地区。
更新日期：2020-08-21
Annals of Indian Academy of Neurology ( IF 1.7 ) Pub Date : 2020-07-01 , DOI: 10.4103/aian.aian_409_19 Sanjith Aaron 1 , Jeyaseelan Lakshmanan 2 , Thambu D Sudarsanam 3 , Kenneth Benjamin 4 , Jothilakshmi Durairaj 2 , Vivek Mathew 1 , Ajith Sivadasan 1 , A T Prabhakar 4 , Shyam Kumar N Keshava 4 , Pavitra R Mannam 4 , Prabhu Kirubakaran 1 , Jayaprakash Muliyil 5 , Mathew Alexander 1
Affiliation
Background and Purpose: Studies looking at seasonal variation on cerebral venous thrombosis (CVT) are few with conflicting conclusions. In this region-specific study, we looked for climatic influence and seasonal trends on the incidence of CVT. Methods: Imaging proven adult CVT cases treated over a period of 18 years from a specific geographical location with similar seasons and climatic conditions were studied. Metrological parameters prepared using 30 years of data was used. Quantum geographical information system (QGIS software) and SPSS v 22 were used for patient plotting and analysis. Results: Total of 970 cases were studied. The incidence was significantly higher in summer 411 (42.3%) compared with autumn 317 (32.7%) and winter 242 (25.05); P = 0.038. This trend was consistent across all the 18 years in time series analysis. Mean age was 33.5 years (range 18–88 years). A significant majority 673 (69.4%) were below 40 years of age; P = 0.012. Females constituted 394 (40.6%) of cases. Postpartum CVT cases constituted 237 (30%). Interaction analysis showed younger age (<40 years) were more vulnerable for CVT in summer; P = 0.009. There was no seasonal influence on postpartum CVT. Apart for a weak positive correlation between rain fall (r = 0.18, P < 0.01); humidity and cloud cover was not influencing the incidence. Conclusions: Higher ambient temperatures were consistently associated with higher incidence of CVT. This is the largest region-specific study on CVT in the world. These results may be applicable to other regions with similar climatic conditions.
中文翻译：
脑静脉血栓形成、季节性趋势和气候影响：特定地区的研究
背景和目的：关于脑静脉血栓形成 (CVT) 季节性变化的研究很少得出相互矛盾的结论。在这项针对特定地区的研究中，我们寻找气候对 CVT 发病率的影响和季节性趋势。方法：研究了从具有相似季节和气候条件的特定地理位置接受治疗超过 18 年的影像学证实成人 CVT 病例。使用了使用 30 年数据准备的计量参数。量子地理信息系统（QGIS 软件）和 SPSS v 22 用于患者绘图和分析。结果：共研究了970例。夏季411（42.3%）的发病率明显高于秋季317（32.7%）和冬季242（25.05）；磷= 0.038。这一趋势在所有 18 年的时间序列分析中都是一致的。平均年龄为 33.5 岁（范围 18-88 岁）。大多数 673 (69.4%) 人年龄在 40 岁以下；P = 0.012。女性占 394 例（40.6%）。产后 CVT 病例占 237 例 (30%)。交互作用分析显示，年龄较小（<40 岁）在夏季更容易发生 CVT；P = 0.009。对产后 CVT 没有季节性影响。除了降雨量之间呈弱正相关（r = 0.18，P < 0.01）；湿度和云量对发病率没有影响。结论：较高的环境温度始终与较高的 CVT 发生率相关。这是世界上最大的针对 CVT 的地区性研究。这些结果可能适用于其他气候条件相似的地区。
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