Depending on the concentration of the drug and/or the method of administration, drugs could be used in various ways. To take full advantage of the drug beneficial properties in oral medical interventions but also in other types of surgery, like plastic surgery, general surgery, or gynecological surgery, the drug concentration as well as the administration method itself will depend on the wound, type of surgery, and severity of the postoperative pain which can be very different. Generally, the local administration methods are recommended. Piroxicam, a nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class, is generally used to relieve the symptoms of pain and inflammation. Starting from the idea of the special benefit of the interference between collagen-based materials and drug beneficial properties, our work was focused on the synthesis and characterization of new collagen-piroxicam materials. These new collagen-based materials present a good water absorption, and the piroxicam release suggests a biphasic drug release profile whereas the obtained values for the release exponent revealed a complex release mechanism including swelling, diffusion, and erosion.

中文翻译：

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用于医疗应用的吡罗昔康-胶原蛋白海绵

取决于药物的浓度和/或给药方法，可以以各种方式使用药物。为了在口服医疗干预中以及在其他类型的手术中充分利用药物的有益特性，例如整形外科，普外科或妇科外科手术，药物浓度以及给药方法本身将取决于伤口，伤口的类型手术和术后疼痛的严重程度可能有很大不同。通常，建议使用本地管理方法。吡罗昔康是奥昔康类的非甾体类抗炎药（NSAID），通常用于缓解疼痛和炎症症状。从胶原蛋白材料之间的干扰和药物有益特性之间的特殊好处的想法开始，我们的工作集中于新型胶原-吡罗昔康材料的合成和表征。这些新的基于胶原蛋白的材料具有良好的吸水性，吡罗昔康的释放表明是双相的药物释放曲线，而所获得的释放指数值显示了复杂的释放机制，包括溶胀，扩散和侵蚀。