当前位置：
X-MOL 学术
›
ACS Appl. Bio Mater.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Ultrashort Peptides—A Glimpse into the Structural Modifications and Their Applications as Biomaterials
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-08-20 , DOI: 10.1021/acsabm.0c00544 Rudradip Das 1 , Bhavinkumar Gayakvad 2 , Suchita Dattatray Shinde 1 , Jyoti Rani 1 , Alok Jain 2 , Bichismita Sahu 1
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-08-20 , DOI: 10.1021/acsabm.0c00544 Rudradip Das 1 , Bhavinkumar Gayakvad 2 , Suchita Dattatray Shinde 1 , Jyoti Rani 1 , Alok Jain 2 , Bichismita Sahu 1
Affiliation
|
Because of their commanding properties, ultrashort and short peptides are gaining significance as viable candidates for molecular self-assembly, which is a naturally inspired approach for developing supramolecular structures and can be used to design various strategies of significance in the field of biomaterials. Self-assembly of biomolecules like proteins, lipids, and nucleic acids is observed in living organisms, various biological-process-based examples like amyloid-β plaque formation, lipid bilayer assembly, and the complementary binding of the nucleotide bases of nucleic acids involve self-assembly. Among all biomolecules, peptide-based self-assembly has the advantage of the availability of the source, peptides can be easily synthesized or obtained from the natural degradation process and can be engineered to modulate their action, making them an area of immense interest for research. Multiple modification options provide a wide area for the engineering of amino acid sequences. Understanding of the amino acid residues with their existing properties and modified properties is very helpful for further improvements. Computational approaches like molecular dynamics simulations provide atomistic-level insight into the self-assembly process, by which newer physical-chemical modifications can be planned. Virtual screening of the peptides on the basis of their properties and probability for the desired activity are helpful as well. Engineered and programmed peptides have been reported for various applications like drug delivery and target specific formulations. A combined approach of computational and experimental studies is helpful to understand and optimize the self-assembly process and mechanism at the atomic level. These self-assembled ultrashort peptides have been used in a wide range of applications from hydrogels to drug delivery agents, biosensors, emulsifiers, and so on.
中文翻译：
超短肽——结构修饰及其作为生物材料的应用一瞥
由于它们的控制特性，超短肽和短肽作为分子自组装的可行候选者越来越重要，这是一种开发超分子结构的自然启发方法，可用于设计生物材料领域的各种重要策略。在生物体中观察到蛋白质、脂质和核酸等生物分子的自组装，各种基于生物过程的例子，如淀粉样蛋白-β斑块形成、脂质双层组装和核酸核苷酸碱基的互补结合都涉及自组装。 -部件。在所有生物分子中，基于肽的自组装具有来源可得的优势，肽可以很容易地合成或从自然降解过程中获得，并且可以通过工程改造来调节它们的作用，使它们成为研究领域的巨大兴趣。多种修饰选项为氨基酸序列工程提供了广阔的领域。了解氨基酸残基及其现有特性和修饰特性对进一步改进非常有帮助。分子动力学模拟等计算方法提供了对自组装过程的原子级洞察力，从而可以计划更新的物理化学修饰。根据肽的特性和所需活性的可能性对肽进行虚拟筛选也很有帮助。工程和程序化的肽已被报道用于各种应用，如药物输送和靶向特定配方。计算和实验研究相结合的方法有助于在原子水平上理解和优化自组装过程和机制。这些自组装的超短肽已被广泛应用于从水凝胶到药物递送剂、生物传感器、乳化剂等。
更新日期：2020-09-21
中文翻译：
超短肽——结构修饰及其作为生物材料的应用一瞥
由于它们的控制特性，超短肽和短肽作为分子自组装的可行候选者越来越重要，这是一种开发超分子结构的自然启发方法，可用于设计生物材料领域的各种重要策略。在生物体中观察到蛋白质、脂质和核酸等生物分子的自组装，各种基于生物过程的例子，如淀粉样蛋白-β斑块形成、脂质双层组装和核酸核苷酸碱基的互补结合都涉及自组装。 -部件。在所有生物分子中，基于肽的自组装具有来源可得的优势，肽可以很容易地合成或从自然降解过程中获得，并且可以通过工程改造来调节它们的作用，使它们成为研究领域的巨大兴趣。多种修饰选项为氨基酸序列工程提供了广阔的领域。了解氨基酸残基及其现有特性和修饰特性对进一步改进非常有帮助。分子动力学模拟等计算方法提供了对自组装过程的原子级洞察力，从而可以计划更新的物理化学修饰。根据肽的特性和所需活性的可能性对肽进行虚拟筛选也很有帮助。工程和程序化的肽已被报道用于各种应用，如药物输送和靶向特定配方。计算和实验研究相结合的方法有助于在原子水平上理解和优化自组装过程和机制。这些自组装的超短肽已被广泛应用于从水凝胶到药物递送剂、生物传感器、乳化剂等。
京公网安备 11010802027423号