Smart Nanosized Drug Delivery Systems Inducing Immunogenic Cell Death for Combination with Cancer Immunotherapy.,Accounts of Chemical Research

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Smart Nanosized Drug Delivery Systems Inducing Immunogenic Cell Death for Combination with Cancer Immunotherapy.
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2020-08-20 , DOI: 10.1021/acs.accounts.0c00254
Lei Zhou _{1,

2} , Pengcheng Zhang _{1,

3} , Hao Wang ₂ , Dangge Wang _{1,

3} , Yaping Li _{1,

3}

Affiliation

Cancer immunotherapy, which suppresses tumor relapse and metastasis by boosting host immunity and inducing long-term immune memory effects, is emerging as a vital approach to improve the prognosis of patients. Although remarkable efficacy has been observed in some patients, challenges including low response rate, drug resistance, and immune-related adverse effects still limit the clinical application of cancer immunotherapy in broad types of tumors. Immunotherapeutic agents are used to enhance tumor immunogenicity and reverse the effects of the immunosuppressive tumor microenvironment (ITM), but the benefits of monotherapy are mild and transient due to off-target distribution of drugs. To overcome these issues, smart nanosized drug delivery systems (sNDDS) have been developed to enhance tissue specificity, co-deliver multiple drugs, prime immune cells, and amplify immune responses in tumors. Moreover, accumulating knowledge in cancer biology, immunology, and material science has also greatly promoted the development of sNDDS for enhancing cancer immunotherapy.

中文翻译：

智能纳米药物输送系统，与癌症免疫疗法相结合，可诱导免疫原性细胞死亡。

通过增强宿主免疫力和诱导长期免疫记忆效应来抑制肿瘤复发和转移的癌症免疫疗法正在成为改善患者预后的重要方法。尽管已在某些患者中观察到了显着的疗效，但包括低应答率，耐药性和免疫相关不良反应在内的挑战仍然限制了癌症免疫疗法在多种类型肿瘤中的临床应用。免疫治疗剂用于增强肿瘤的免疫原性并逆转免疫抑制肿瘤微环境（ITM）的作用，但是由于药物的脱靶分布，单一疗法的益处是温和的和短暂的。为了克服这些问题，已经开发了智能纳米尺寸的药物输送系统（sNDDS），以增强组织特异性，共同输送多种药物，启动免疫细胞，并增强肿瘤的免疫反应。此外，在癌症生物学，免疫学和材料科学方面积累的知识也极大地促进了用于增强癌症免疫疗法的sNDDS的发展。

更新日期：2020-09-15

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