Abstract

The systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) are a diseases in which disturbances in plasma proteins glycosylation exist. The aim of the study was to compare the serum profile of transferrin isoforms between SLE and SSc. The study was carried out in 38 patients with SLE and 43 patients with SSc. Transferrin isoforms were analyzed by capillary electrophoresis method. Among the transferrin isoforms only the level of pentasialotransferrin in SLE patients was significantly higher than in SSc patients (p = .014). The median concentrations of trisialotransferrin and pentasialotransferrin were significantly lower in SLE patients (p < .001, p = .042; respectively) and SSc (p = .001, p < .001; respectively) than in the healthy subjects. In contrast, the level of tetrasialotransferrin manifested significant increase in comparison to the controls (p < .001 for all comparisons). The serum profile of transferrin isoforms alters in SLE and SSc but only level of pentasialotransferrin differs between SLE and SSc patients. We confirm that the serum profile of transferrin isoforms in SLE and SSc is unique to these diseases.

摘要

系统性红斑狼疮 (SLE) 和系统性硬化症 (SSc) 是一种存在血浆蛋白糖基化紊乱的疾病。该研究的目的是比较 SLE 和 SSc 之间转铁蛋白同种型的血清特征。该研究在 38 名 SLE 患者和 43 名 SSc 患者中进行。通过毛细管电泳法分析转铁蛋白同种型。在转铁蛋白同种型中，只有 SLE 患者的五唾液酸转铁蛋白水平显着高于 SSc 患者 ( p  = .014)。SLE 患者（分别为p  < .001，p  = .042）和 SSc（p  = .001，p < .001; 分别）比健康受试者。相比之下，与对照相比，四唾液酸转铁蛋白的水平显着增加（ 所有比较p < .001）。SLE 和 SSc 中转铁蛋白同种型的血清特征发生变化，但 SLE 和 SSc 患者之间只有五唾液酸转铁蛋白水平不同。我们确认 SLE 和 SSc 中转铁蛋白同种型的血清特征是这些疾病所独有的。