Abstract

An efficient Et₃N/DMAP-assisted approach has been reported for the synthesis of indenopyrimidine sulfonamides from indenopyrimidine-2-amines via S-N bond formation. The various indenopyrimidine-2-amines were synthesized from crotonic acid, corresponding aldehydes and guanidinium hydrochloride using one-pot three-component strategy. The treatment of indenopyrimidine-2-amines with various sulfonyl chlorides in the presence of Et₃N/DMAP in N-methylpyrrolidinone afforded the corresponding sulfonamides in good to excellent yields. All newly synthesized compounds were characterized by ¹H NMR, ¹³C NMR and mass spectral studies.

中文翻译：

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茚并嘧啶-2-胺通过S-N键形成新型茚并嘧啶磺胺类化合物的合成

摘要

已经报道了一种有效的 Et _{3 N/DMAP 辅助方法，用于}通过SN 键形成从茚并嘧啶-2-胺合成茚并嘧啶磺酰胺。以巴豆酸、相应的醛类和盐酸胍为原料，采用一锅三组分策略合成了多种茚并嘧啶-2-胺。在N-甲基吡咯烷酮中，在 Et ₃ N/DMAP存在下，用各种磺酰氯处理茚并嘧啶-2-胺，以良好至优异的产率提供了相应的磺酰胺。所有新合成的化合物均通过¹ H NMR、¹³ C NMR 和质谱研究进行了表征。