Abstract

A new indolizinium alkaloid, named as cyclizidine J (1), was identified from Gause’s liquid fermentation of marine-derived Streptomyces sp. HNA39. Its structure was elucidated by extensive NMR spectroscopic methods, HRESIMS data, and ECD calculations. To our best knowledge, compound 1 was a unique cyclizidine-type alkaloid that contain a chlorine atom substituted at position C-8. Unfortunately, biological evaluation of 1 exhibited no active against PC-3 cancer cell line, BRD4, and ROCK2 protein kinase.

中文翻译：

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来自海洋来源的链霉菌属的新 indolizinium 生物碱。海航39

摘要

从高斯对海洋来源的链霉菌属的液体发酵中鉴定出一种新的茚茚生物碱，命名为环里西啶 J ( 1 ) 。海航39. 通过广泛的 NMR 光谱方法、HRESIMS 数据和 ECD 计算阐明了其结构。据我们所知，化合物1是一种独特的环西啶型生物碱，其 C-8 位上有一个氯原子被取代。不幸的是，1 的生物学评估显示对 PC-3 癌细胞系、BRD4 和 ROCK2 蛋白激酶没有活性。