Abstract

Herbicide-resistant weeds are a growing problem worldwide. Thaxtomin phytotoxins are a group of nitrated diketopiperazines produced by the potato common scab-causing pathogen Streptomyces scabies and other actinobacterial plant pathogens. They represent a unique class of microbial natural products with distinctive structural features and promising herbicidal activity. The biosynthesis of thaxtomins proceeds through multiple steps of unusual enzymatic reactions. Advances in understanding of thaxtomins biosynthetic machinery have provided the basis for precursor-directed biosynthesis, pathway refactoring, and one-pot biocombinatorial synthesis to generate thaxtomin analogues. We herein summarize recent findings on the biosynthesis of thaxtomins and highlight recent advances in the rational generation of novel thaxtomins for the development of potent herbicidal agents.

摘要

抗除草剂杂草在世界范围内是一个日益严重的问题。thaxtomin phytotoxins是由马铃薯常见结ab病致病性链霉菌sc疮产生的一组硝化二酮哌嗪和其他放线菌植物病原体。它们代表一类独特的微生物天然产物，具有独特的结构特征和有希望的除草活性。凝血酶原的生物合成通过不寻常的酶促反应的多个步骤进行。对Thaxtomins生物合成机制的了解的进步为前驱体定向生物合成，途径重构和一锅生物组合合成以产生thaxtomin类似物提供了基础。我们在本文中总结了关于Thaxtomin生物合成的最新发现，并着重指出了为有效除草剂的发展合理产生新型Thaxtomins的最新进展。